TABLE 6.

Sensitivity, specificity, and positive and negative predictive values of vancomycin concentrations at T3 for predicting AUC_0–24/MIC ratios of ≥400 at different MICs^a

Vancomycin concn (mg/liter) at T3 and predictive measure	Value (%) for predicting anAUC0–24/MIC ratio of ≥400 at a MIC (mg/liter) of:
	0.5	1.0	1.5	2.0
≥15
Sensitivity	95	96	100	100
Specificity	100	100	31	6
PPV	100	100	89	26
NPV	0	20	100	100
≥20
Sensitivity	78	78	87	94
Specificity	100	100	75	37
PPV	100	100	95	57
NPV	0	4	50	88
≥25
Sensitivity	37	37	43	70
Specificity	100	100	100	93
PPV	100	100	100	90
NPV	0	2	24	78
≥30
Sensitivity	21	21	24	44
Specificity	100	100	100	100
PPV	100	100	100	100
NPV	0	1	19	67

^aT3, 24 h after the initiation of therapy; AUC_0–24/MIC ratio, ratio between the area under the curve of drug concentrations over the first day of therapy and the MIC.