TABLE 2.
PK parameters for GHQ168, GHQ242, and GHQ243a
| Compound | Mouse no. | t1/2 (h) | CL (ml/h) | V (liters/kg BW) | AUC0–∞ (ng · h/ml) |
|---|---|---|---|---|---|
| GHQ168 | 1 | 1.6 | 93 | 8 | 945 |
| 2 | 2.3 | 118 | 15 | 742 | |
| 3 | 2.6 | 125 | 19 | 701 | |
| GHQ242 | 1 | * | * | * | * |
| 2 | 3.7 | 4,792 | 1,014 | 120 | |
| 3 | 23 | 4,232 | 5,608 | 135 | |
| 4 | 2.3 | 2,686 | 357 | 213 | |
| GHQ243 | 1 | 2.4 | 402 | 55 | 1,350 |
| 2 | 3.1 | 819 | 148 | 663 | |
| 3 | 2.3 | 693 | 92 | 784 | |
| 4 | 1.8 | 830 | 86 | 6,542 |
a
t1/2, half-life; CL, clearance; V, volume of distribution; BW, body weight; AUC0–∞, area under the concentration-time curve from time zero to infinity. *, calculation of PK parameters was not possible due to flip-flop kinetics.