FIG 2.

The chemosensitization of macrophages (MØ) by aspirin and ibuprofen. The ability of macrophages to internalize cryptococcal cells in the absence (nontreated cells) and presence of aspirin or ibuprofen was measured using the phagocytosis stain pHrodo green zymosan A BioParticles after 2 h (A) and 6 h (B). Addition of aspirin and ibuprofen significantly enhanced (P > 0.05) the ability of macrophages to internalize cryptococci compared to that of no treatment at both times. This further indicates that the two drugs do not negatively affect macrophages, as suggested in Fig. 1. Ethanol (EToH), DMSO, and beads were included as controls.