TABLE 1.
Effects of aspirin and ibuprofen on metabolic activity of C. neoformans and C. gattii
| Species and strain | OD562a of nontreated cells | % growth reductionb |
|||||
|---|---|---|---|---|---|---|---|
| Aspirin-treated cells |
Ibuprofen-treated cells |
||||||
| 1.80 μg/ml | 18.0 μg/ml | 180 μg/ml | 2.06 μg/ml | 20.6 μg/ml | 206 μg/ml | ||
| C. neoformans | |||||||
| LMPE 028 | 0.403 (0.009) | 11 (0.008) | 32 (0.044) | 71 (0.011) | 13 (0.014) | 36 (0.007) | 75 (0.021) |
| LMPE 030 | 0.411 (0.014) | 10 (0.022) | 34 (0.007) | 72 (0.007) | 12 (0.009) | 37 (0.021) | 74 (0.022) |
| LMPE 043 | 0.398 (0.005) | 12 (0.041) | 31 (0.005) | 70 (0.018) | 13 (0.009) | 34 (0.034) | 75 (0.015) |
| LMPE 046 | 0.402 (0.032) | 14 (0.036) | 38 (0.052) | 74 (0.009) | 16 (0.017) | 40 (0.015) | 76 (0.009) |
| LMPE 047 | 0.401 (0.012) | 13 (0.049) | 35 (0.051) | 73 (0.016) | 14 (0.034) | 37 (0.022) | 74 (0.013) |
| C. gattii | |||||||
| LMPE 045 | 0.401 (0.026) | 10 (0.007) | 30 (0.029) | 70 (0.012) | 11 (0.023) | 32 (0.015) | 73 (0.011) |
| LMPE 048 | 0.400 (0.036) | 12 (0.018) | 32 (0.022) | 72 (0.009) | 13 (0.007) | 33 (0.043) | 74 (0.032) |
| LMPE 052 | 0.390 (0.009) | 10 (0.021) | 29 (0.014) | 69 (0.021) | 12 (0.016) | 31 (0.012) | 71 (0.013) |
| LMPE 054 | 0.401 (0.015) | 11 (0.009) | 31 (0.008) | 70 (0.007) | 12 (0.030) | 32 (0.006) | 72 (0.016) |
| LMPE 070 | 0.394 (0.007) | 10 (0.008) | 30 (0.022) | 70 (0.011) | 11 (0.031) | 31 (0.041) | 71 (0.008) |
a
OD562, OD at 562 nm.
b
Percent growth reduction was calculated as 100% − [(OD of treated cells/OD of nontreated cells) · 100%]. Values represent the mean values from three biological replicates, and values in parentheses represent standard deviations.