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. 2016 Jul 12;7(4):e00474-16. doi: 10.1128/mBio.00474-16

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Copyright © 2016 Yu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — Model of interaction between ACBD3 and SseF and SseG. (A) ACBD3 (blue) interacts with the integral membrane protein giantin (red) at the Golgi network. In the absence of SseG, SseF assumes a closed conformation and is unable to interact with ACBD3. (B) When both SseG and SseF are present, they interact. This changes their conformations to allow them to interact with ACBD3. (C) A point mutant of SseG (SseG^S67G) is unable to interact with ACBD3 but remains functional by enabling SseF to interact with ACBD3. (D) A double mutant of SseF (SseF^C109W,D129G) is unable to interact with ACBD3 but remains functional by enabling SseG to interact with ACBD3. (E) Simultaneous disruption of SseF-ACBD3 and SseG-ACBD3 interactions by coexpression of mutant forms of both SseF and SseG prevents SCVs from stable association with the Golgi network. (F) Depletion of ACBD3 prevents SCVs from associating with the Golgi network.