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EC50s for stage V gametocytes of the CRISPR/Cas9-engineered NF54 parasite line for GNF179 and puromycina
| Gene mutated (technique) | Mutation introduced | GNF179 EC50 (nM) | Fold increase | Puromycin EC50 (nM) | Fold increase |
|---|---|---|---|---|---|
| NA | NA | 8.8 ± 2.7 | NA | 100 ± 40 | NA |
| pfcarl (CRISPR) | L830V | 2,550 ± 780 | 290 | 90 ± 15 | 0.9 |
EC50s for the stage V gametocytes were determined using the MitoTracker red assay and are listed as means + SE (n = 3). NA, not applicable.
