TABLE 3.

Fecal MK concentrations of male and female mice fed a control or vitamin K–deficient diet for 28 d¹

	Deficient diet			Control diet			P
Vitamin K form, pmol/g	Male	Female	P	Male	Female	P	Sex	Diet	Sex × diet interaction
PK	28.1 ± 9.95	20.3 ± 7.2	0.98	1920 ± 678	2410 ± 853	0.02	0.08	<0.01†	0.08
MK4	859 ± 304	568 ± 201	0.88	1080 ± 381	1190 ± 421	0.67	0.68	<0.01†	0.84
MK5	ND	ND	—	ND	ND	—	—	—	—
MK6	142 ± 50.3	202 ± 71.5	0.94	79.3 ± 28.1	383 ± 135	0.01*	0.07	0.75	0.06
MK7	44.4 ± 15.7	55 ± 19.4	0.95	29.1 ± 10.3	ND	—	0.53	0.06	0.48
MK8	125 ± 44.2	219 ± 77.2	0.85	54.6 ± 19.3	212 ± 74.8	0.02	0.08	0.10	0.13
MK9	376 ± 133	180 ± 63.4	0.28	196 ± 69.2	282 ± 99.6	0.22	0.90	0.65	0.11
MK10	804 ± 284	796 ± 282	0.57	581 ± 205	1210 ± 429	0.01*	0.13	0.82	0.02
MK11	224 ± 79.3	274 ± 96.8	0.93	166 ± 58.7	400 ± 142	0.01*	0.07	0.92	0.05
MK12	13.8 ± 4.9	23.3 ± 8.2	0.52	15.2 ± 5.4	32.8 ± 11.6	0.07	0.08	0.59	0.39
MK13	78.1 ± 27.6	59.4 ± 21	0.87	60.3 ± 21.3	104 ± 36.8	0.19	0.41	0.40	0.30

¹Values are means ± SEMs, n = 8 mice/group. Concentration was below lower limit of detection for MK5 and MK7 (5.0 pmol/g) by use of an LC-MS assay. *Significant difference in Tukey’s honestly significant difference test between male and female mice within diet group at P < 0.01 adjusted α level. ^†Significant test within the ANOVA model for specific tissue and vitamin K form at P < 0.01 adjusted significance level. MK, menaquinone; ND, nondetectable; PK, phylloquinone.