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. 2016 Jul 1;9(7):759–767. doi: 10.1242/dmm.025783

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Nf1^4F/4F; DhhCre mice develop neurofibromas and sciatic nerve lesions. (A,B) Gross dissection (A) and H&E staining (B) of spinal tumors in Nf1^4F/4F; DhhCre mice. Red dashed lines demarcate the neurofibroma boundaries. Red arrows indicate neurofibromas. (C,D) The ultrastructure, as shown by electron microscopy, shows similar lesions in the Nf1^4F/Arg681*; DhhCre mice in both neurofibromas (C) and sciatic nerves (D). Black arrows indicate abnormal nonmyelinating axons. The magnifications are as indicated. Scale bars: 4 μm in C,D.