Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 1;143(13):2431–2442. doi: 10.1242/dev.135004

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 4. — Ectopic Abd-B affects Dpp-dependent EMT and progenitor differentiation in the IPC. (A-B′) Unlike in controls (A,A′), dpp-lacZ expression (blue) at the anterior-posterior boundary (arrow) was repressed in Pcl^3-78*38 ELF mosaic wing imaginal discs (B,B′, asterisk). (C-E) Unlike in controls (C), Pcl^3-78*38 ELF mosaics (D) showed small Fas3-positive (red) clusters (arrowheads) close to the p-IPC (dashed line). These were dpp-lacZ negative (blue, D′) and Abd-B positive (red, E, inset). (F) hs-FLPout clones (green) expressing ectopic Abd-B formed small clusters (arrowheads) adjacent to p-IPC (dashed line) subdomains and downregulated dpp-lacZ (blue; inset, white; arrowheads). (G) Model of Pcl function in p-IPC subdomains. (H-J′) Progenitor cell streams between the p-IPC and d-IPC in esg^MH766-Gal4, UAS-cd8GFP (green) animals did not express Ase (blue) (H,H′). Pcl^3-78*38 mutant progenitors (green) generated by MARCM ectopically expressed Ase (blue, arrows) (I,I′). Ectopic expression of Abd-B using the hs-FLPout approach had the same effect (J,J′, arrows). For genotypes and sample numbers, see Table S1. Scale bars: 50 µm.