Table 3.
Distribution of the genotype and allele of SNPs in BDNF and NGF genes in all groups
| Gene | rs number | Group | N | Genotypes (N, freq) | Alleles (N, freq) | |||
|---|---|---|---|---|---|---|---|---|
| BDNF | rs6265(G/A) | GG | GA | AA | G | A | ||
| Migraine | 288 | 196 (0.681) | 84 (0.292) | 8 (0.028) | 476 (0.826) | 100 (0.174) | ||
| MA | 112 | 75 (0.670) | 35 (0.312) | 2 (0.018) | 185 (0.826) | 39 (0.174) | ||
| MO | 176 | 121 (0.688) | 49 (0.278) | 6 (0.034) | 291 (0.827) | 61 (0.173) | ||
| HC | 288 | 217 (0.753) | 66 (0.229) | 5 (0.017) | 500 (0.868) | 76 (0.132) | ||
| BDNF | rs925946(G/T) | GG | GT | TT | G | T | ||
| Migraine | 288 | 183 (0.635) | 94 (0.326) | 11 (0.038) | 460 (0.799) | 116 (0.201) | ||
| MA | 112 | 68 (0.607) | 41 (0.366) | 3 (0.027) | 177 (0.790) | 47 (0.210) | ||
| MO | 176 | 115 (0.653) | 53 (0.301) | 8 (0.045) | 283 (0.804) | 69 (0.196) | ||
| HC | 288 | 174 (0.604) | 97 (0.337) | 17 (0.059) | 445 (0.773) | 131 (0.227) | ||
| BDNF | rs2049046(A/T) | AA | AT | TT | A | T | ||
| Migraine | 288 | 64 (0.222) | 147 (0.510) | 77 (0.267) | 275 (0.477) | 301 (0.523) | ||
| MA | 112 | 26 (0.232) | 60 (0.536) | 26 (0.232) | 112 (0.500) | 112 (0.500) | ||
| MO | 176 | 38 (0.216) | 87 (0.494) | 51 (0.290) | 163 (0.463) | 189 (0.537) | ||
| HC | 288 | 82 (0.285) | 128 (0.444) | 78 (0.271) | 292 (0.507) | 284 (0.493) | ||
| BDNF | rs12273363(T/C) | TT | TC | CC | T | C | ||
| Migraine | 288 | 224 (0.778) | 62 (0.215) | 2 (0.007) | 510 (0.885) | 66 (0.115) | ||
| MA | 112 | 84 (0.750) | 28 (0.250) | 0 (0.000) | 196 (0.875) | 28 (0.125) | ||
| MO | 176 | 140 (0.795) | 34 (0.193) | 2 (0.011) | 314 (0.892) | 38 (0.108) | ||
| HC | 288 | 212 (0.736) | 69 (0.240) | 7 (0.024) | 493 (0.856) | 83 (0.144) | ||
| NGF | rs6330(C/T) | CC | CT | TT | C | T | ||
| Migraine | 262 | 115 (0.439) | 114 (0.435) | 33 (0.126) | 344 (0.656) | 180 (0.344) | ||
| MA | 90 | 32 (0.356) | 41 (0.456) | 17 (0.189) | 105 (0.583) | 75 (0.417) | ||
| MO | 172 | 83 (0.483) | 73 (0.424) | 16 (0.093) | 239 (0.695) | 105 (0.305) | ||
| HC | 288 | 140 (0.486) | 119 (0.413) | 29 (0.101) | 399 (0.693) | 177 (0.307) | ||
| NGF | rs11102930(C/A) | CC | CA | AA | C | A | ||
| Migraine | 281 | 75 (0.267) | 148 (0.527) | 58 (0.206) | 298 (0.530) | 264 (0.470) | ||
| MA | 107 | 31 (0.290) | 53 (0.495) | 23 (0.215) | 115 (0.537) | 99 (0.463) | ||
| MO | 174 | 44 (0.253) | 95 (0.546) | 35 (0.201) | 183 (0.526) | 165 (0.474) | ||
| HC | 288 | 76 (0.264) | 147 (0.510) | 65 (0.226) | 299 (0.519) | 277 (0.481) | ||
| NGF | rs4839435(G/A) | GG | GA | AA | G | A | ||
| Migraine | 288 | 270 (0.938) | 18 (0.062) | 0 (0.0) | 558 (0.969) | 18 (0.031) | ||
| MA | 112 | 105 (0.938) | 7 (0.062) | 0 (0.0) | 217 (0.969) | 7 (0.031) | ||
| MO | 176 | 165 (0.938) | 11 (0.062) | 0 (0.0) | 341 (0.969) | 11 (0.031) | ||
| HC | 288 | 277 (0.962) | 11 (0.038) | 0 (0.0) | 565 (0.981) | 11 (0.019) |
Abbreviations: BDNF, brain-derived neurotrophic factor; freq, frequency; HC, healthy control; MA, migraine with aura; MO, migraine without aura; NGF, nerve growth factor; SNP, single-nucleotide polymorphism.