Table 4.
Chi-square analysis of the allelic and genotypic frequencies in all migraine groups and controls for all studied SNPs
| Subjects | Genotypes
|
Alleles
|
|||||
|---|---|---|---|---|---|---|---|
| χ2 | df | P-value | χ2 | df | P-value | ORs (95% CIs) | |
| BDNF rs6265 | |||||||
| Migraine vs HC | 3.920 | 2 | 0.141 | 3.862 | 1 | 0.049 | 0.723 (0.523–0.999) |
| MA vs HC | 2.995 | 2 | 0.223 | 2.329 | 1 | 0.127 | 0.721 (0.473–1.099) |
| MO vs HC | 3.011 | 2 | 0.221 | 2.968 | 1 | 0.085 | 0.725 (0.502–1.046) |
| MA vs MO | 0.954 | 2 | 0.621 | 0.001 | 1 | 0.980 | 1.006 (0.646–1.565) |
| BDNF rs925946 | |||||||
| Migraine vs HC | 1.559 | 2 | 0.458 | 1.159 | 1 | 0.281 | 1.167 (0.881–1.547) |
| MA vs HC | 1.877 | 2 | 0.391 | 0.289 | 1 | 0.591 | 1.108 (0.761–1.614) |
| MO vs HC | 1.228 | 2 | 0.541 | 1.275 | 1 | 0.259 | 1.207 (0.870–1.675) |
| MA vs MO | 1.739 | 2 | 0.419 | 0.162 | 1 | 0.687 | 1.089 (0.718–1.650) |
| BDNF rs2049046 | |||||||
| Migraine vs HC | 3.538 | 2 | 0.170 | 1.003 | 1 | 0.316 | 1.125 (0.893–1.418) |
| MA vs HC | 2.719 | 2 | 0.256 | 0.031 | 1 | 0.859 | 1.028 (0.755–1.399) |
| MO vs HC | 2.727 | 2 | 0.255 | 1.683 | 1 | 0.194 | 1.192 (0.914–1.555) |
| MA vs MO | 1.161 | 2 | 0.559 | 0.748 | 1 | 0.387 | 1.159 (0.829–1.621) |
| BDNF rs12273363 | |||||||
| Migraine vs HC | 3.482 | 2 | 0.175 | 2.227 | 1 | 0.135 | 0.768 (0.544–1.086) |
| MA vs HC | 2.779 | 2 | 0.249 | 0.492 | 1 | 0.483 | 0.848 (0.536–1.343) |
| MO vs HC | 2.510 | 2 | 0.285 | 2.517 | 1 | 0.113 | 0.719 (0.477–1.082) |
| MA vs MO | 2.481 | 2 | 0.289 | 0.392 | 1 | 0.531 | 0.847 (0.504–1.424) |
| NGF rs6330 | |||||||
| Migraine vs HC | 1.591 | 2 | 0.451 | 1.642 | 1 | 0.200 | 1.179 (0.916–1.518) |
| MA vs HC | 7.242 | 2 | 0.026a | 7.382 | 1 | 0.007 | 1.610 (1.140–2.274) |
| MO vs HC | 0.100 | 2 | 0.951 | 0.004 | 1 | 0.948 | 0.990 (0.741–1.323) |
| MA vs MO | 6.613 | 2 | 0.036a | 6.506 | 1 | 0.011 | 1.626 (1.117–2.365) |
| NGF rs11102930 | |||||||
| Migraine vs HC | 0.322 | 2 | 0.851 | 0.141 | 1 | 0.706 | 1.045 (0.829–1.319) |
| MA vs HC | 0.267 | 2 | 0.874 | 0.209 | 1 | 0.647 | 1.076 (0.785–1.473) |
| MO vs HC | 0.614 | 2 | 0.735 | 0.039 | 1 | 0.842 | 1.027 (0.787–1.341) |
| MA vs MO | 0.721 | 2 | 0.697 | 0.071 | 1 | 0.790 | 0.954 (0.678–1.343) |
| NGF rs4839435 | |||||||
| Migraine vs HC | 1.779 | 1 | 0.182 | 1.733 | 1 | 0.188 | 1.657 (0.775–3.539) |
| MA vs HC | 1.108 | 1 | 0.292 | 1.083 | 1 | 0.298 | 1.657 (0.634–4.329) |
| MO vs HC | 1.429 | 1 | 0.232 | 1.394 | 1 | 0.237 | 1.657 (0.711–3.863) |
| MA vs MO | 0.000 | 1 | 1.000 | 0.000 | 1 | 1.000 | 1.000 (0.382–2.619) |
Notes: Statistically significant results are given in bold. aThe significance was not maintained after Bonferroni adjustment (Pcorrected,0.017 [0.05/3]).
Abbreviations: BDNF, brain-derived neurotrophic factor; χ2, chi-square; df, degrees of freedom; HC, healthy control; MA, migraine with aura; MO, migraine without aura; NGF, nerve growth factor; ORs (95% CIs), odds ratios (95% confidence intervals); SNPs, single-nucleotide polymorphisms.