Table 2.
Complications, response rate, and survival by treatment regimen.
| RCHOP | RChOP | RCOP | p value | |
|---|---|---|---|---|
| N (%) | 53 (100) | 48 (100) | 40 (100) | — |
|
| ||||
| Complications of treatment | ||||
|
| ||||
| Infections | — | — | — | |
| None | 18 (33.96) | 14 (29.17) | 23 (57.5) | 0.09 |
| Ambulatory treated | 15 (22.64) | 12 (25.0) | 10 (25) | |
| Febrile neutropenia (FN) | 12 (22.64) | 11 (22.92) | 4 (10) | |
| Other than FN, requiring hospitalization | 8 (15.09) | 11 (22.92) | 3 (7.5) | |
|
| ||||
| Myelosuppression | — | — | — | |
| None | 36 (67.92) | 30 (62.5) | 26 (65) | 0.94 |
| No transfusion required | 6 (11.32) | 8 (16.67) | 5 (12.5) | |
| Required transfusion | 11 (20.75) | 10 (20.83) | 9 (22.5) | |
|
| ||||
| Other complications (G III-IV) | — | — | — | |
| None | 28 (52.83) | 17 (35.42) | 24 (60) | 0.359 |
| Pain | 3 (5.66) | 4 (8.33) | 2 (5) | |
| 2nd malignancy | 0 | 1 (2.08) | 0 | |
| Neuropathy | 1 (1.89) | 5 (10.42) | 2 (5) | |
| Lung | 0 | 1 (2.08) | 0 | |
| Thrombosis | 1 (1.89) | 3 (6.25) | 0 | |
| Cardiovascular | 8 (15.09) | 5 (10.42) | 6 (15) | |
| Gastrointestinal | 8 (15.09) | 5 (10.42) | 6 (15) | |
| Renal | 4 (7.55) | 7 (14.58) | 2 (5) | |
|
| ||||
| Required radiotherapy | 22 (41.51) | 17 (35.42) | 18 (45) | 0.065 |
|
| ||||
| Response | — | — | — | |
| Complete | 35 (66.04) | 30 (62.5) | 21 (52.5) | |
| Partial | 6 (11.32) | 3 (6.25) | 3 (7.5) | 0.418 |
| Stable disease | 0 | 0 | 1 (2.5) | |
| Progressive disease | 2 (3.77) | 6 (12.5) | 3 (7.5) | |
| Not evaluated | 10 (18.87) | 9 (18.75) | 12 (30) | |
|
| ||||
| Relapsed | 6 (11.32) | 6 (12.5) | 7 (17.5) | 0.668 |
|
| ||||
| Mean disease-free survival (95% IC) | 34.72 (29.54–39.89) | 27.77 (22.28–33.25) | 24.99 (18.9–31.09) | >0.05∗ |
|
| ||||
| Mean overall survival (95% IC) | 35.8 (30.56–41.05) | 27.69 (22.18–33.2) | 44.29 (32.65–55.93) | >0.05∗ |
∗Restricted mean.