Table 1.
Differentially expressed mitochondria associated genes in RC77T/E versus RC77N/E.
| Gene ID | Gene | Fold change | p value | Mitochondrial function |
|---|---|---|---|---|
| ATP5F1 | ATP synthase F(0) complex subunit B1 | 2.335 | 0.003692 | Complex V (ATP synthase) |
| ATP5G1 | ATP synthase F(0) complex subunit C1 | 3.29 | 0.000036 | Complex V (ATP synthase) |
| ATP5G3 | ATP synthase F(0) complex subunit C3 | 2.3634 | 0.000079 | Complex V (ATP synthase) |
| ATP5L | ATP synthase, mitochondrial F0 complex, subunit E | 3.7348 | 0.000572 | Complex V (ATP synthase) |
| BAK1 | BCL2-antagonist/killer 1 | 5.4275 | 0.001285 | Apoptosis, membrane polarization and potential |
| BCL2L1 | BCL2-like 1 | 2.5872 | 0.000284 | Apoptosis, membrane polarization and potential |
| BID | BH3 interacting domain death agonist | 2.1975 | 0.000056 | Apoptosis, membrane polarization and potential |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | 3.863 | 0.000005 | Apoptosis |
| CPT2 | Carnitine palmitoyltransferase 2 | 2.2704 | 0.007064 | Mitochondrial transport, import of palmitoyl-CoA |
| DNM1L | Dynamin 1-like | 3.3432 | 0.000016 | Apoptosis, mitochondrial localization |
| GRPEL1 | GrpE-like 1, mitochondrial | 3.1984 | 0.000099 | Targeting proteins to mitochondria, protein import |
| HSP90AA1 | Heat shock protein 90 kDa alpha (cytosolic), class A member 1 | 3.7062 | 0.000006 | Mitochondrial transport, molecular chaperone |
| HSPA1A | Heat shock 70 kDa protein 1A | 2.478 | 0.000413 | Molecular chaperone |
| HSPA1B | Heat shock 70 kDa protein 1B | 2.405 | 0.031481 | Molecular chaperone |
| HSPD1 | Heat shock 60 kDa protein 1 (chaperonin) | 2.1902 | 0.000003 | Mitochondrial transport, mitochondria chaperone |
| MSTO1 | Misato homolog 1 | 2.3655 | 0.000371 | Mitochondrial localization, distribution and morphology |
| NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | 2.864 | 0.000012 | Complex I (NADH-coenzyme Q reductase) |
| NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | 3.705 | 0.000014 | Complex I (NADH-coenzyme Q reductase) |
| NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | 4.3791 | 0.000068 | Complex I (NADH-coenzyme Q reductase) |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5 | 2.0443 | 0.000034 | Complex I (NADH-coenzyme Q reductase) |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7 | 2.1198 | 0.057441 | Complex I (NADH-coenzyme Q reductase) |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2 | 3.5214 | 0.000063 | Complex I (NADH-coenzyme Q reductase) |
| NEFL | Neurofilament, light polypeptide | −4.3762 | 0.000097 | Mitochondrial localization, potential tumor suppressor |
| RHOT2 | Ras homolog gene family, member T2 | 2.0615 | 0.000081 | Mitochondrial localization, mitochondrial trafficking |
| SLC25A13 | Solute carrier family 25, member 13 (citrin) | 3.7679 | 0.000022 | Small molecule transport, aspartate glutamate carrier |
| SLC25A19 | Solute carrier family 25 (thiamine pyrophosphate carrier), member 19 | 2.4244 | 0.000124 | Small molecule transport, thiamine pyrophosphate carrier |
| SLC25A20 | Solute carrier family 25 (carnitine/acylcarnitine), member 20 | 3.5411 | 0.00002 | Small molecule transport, transport of acylcarnitines |
| SLC25A22 | Solute carrier family 25 (glutamate carrier), member 22 | 3.1844 | 0.000272 | Small molecule transport, glutamate/H(+) symporter 1 |
| SLC25A25 | Solute carrier family 25 (phosphate carrier), member 25 | 3.2177 | 0.000105 | Calcium-dependent mitochondrial solute carrier |
| SLC25A25 | Solute carrier family 25 (phosphate carrier), member 25 | 2.3477 | 0.000454 | Calcium-dependent mitochondrial solute carrier |
| SLC25A3 | Solute carrier family 25 (phosphate carrier), member 3 | 2.1644 | 0.000049 | Small molecule transport, phosphate transport |
| SLC25A37 | Solute carrier family 25, member 37 | 2.7408 | 0.000096 | Small molecule transport, mitochondrial iron transporter |
| SOD1 | Superoxide dismutase 1 | 2.5797 | 0.000002 | Membrane polarization and potential, detoxification of ROS |
| SOD2 | Superoxide dismutase 2, mitochondrial | 2.4298 | 0.000013 | Apoptosis, destruction of superoxide anion radicals |
| TIMM10B | Mitochondrial import inner membrane translocase subunit | 2.384 | 0.000082 | Protein import, inner membrane translocation |
| TIMM17A | Translocase of inner mitochondrial membrane 17A | 2.3979 | 0.00002 | Inner membrane translocation |
| TIMM17B | Translocase of inner mitochondrial membrane 17B | 2.1244 | 0.000009 | Inner membrane translocation |
| TIMM22 | Translocase of inner mitochondrial membrane 22 | 2.9497 | 0.000287 | Inner membrane translocation |
| TIMM23 | Translocase of inner mitochondrial membrane 23 | 2.276 | 0.000005 | Inner membrane translocation |
| TIMM50 | Translocase of inner mitochondrial membrane 50 | 2.4393 | 0.000534 | Inner membrane translocation |
| TIMM8B | Translocase of inner mitochondrial membrane 8B | 2.2896 | 0.000022 | Inner membrane translocation |
| TOMM22 | Translocase of outer mitochondrial membrane 22 | 2.4539 | 0.000001 | Mitochondrial import receptor |
| TOMM34 | Translocase of outer mitochondrial membrane 34 | 3.579 | 0.000006 | Outer membrane translocation |
| TOMM40 | Translocase of outer mitochondrial membrane 40 | 3.0187 | 0.000026 | Outer membrane translocation |
| TOMM40L | Translocase of outer mitochondrial membrane 40-like | 4.1483 | 0.000108 | Outer membrane translocation |
| TP53 | Tumor protein p53 | 2.0973 | 0.000006 | Tumor suppressor |
| UCP2 | Uncoupling protein 2 | 10.5781 | 0 | Transport, uncoupling oxidative phosphorylation |
| UQCRQ | Cytochrome b-c1 complex subunit 8 | 2.2169 | 0.000029 | Complex III (coenzyme Q-cytochrome c reductase) |