Table 2.
Top five canonical pathways associated with differentially expressed genes between RC77T/E and RC77N/E.
| # | Ingenuity canonical pathways | −log(p value) | Ratio | Molecules |
|---|---|---|---|---|
| 1 | Mitochondrial dysfunction | 1.62E + 01 | 7.88E − 02 | UCP2, RHOT2, NDUFS7, ATP5G1, ATP5F1, SOD2, ATP5L, NDUFB6, NDUFA8, UQCRQ, NDUFS5, NDUFV2, ATP5G3 |
| 2 | Oxidative phosphorylation | 1.33E + 01 | 9.62E − 02 | ATP5L, NDUFB6, NDUFA8, UQCRQ, ATP5G1, NDUFS7, ATP5F1, NDUFS5, NDUFV2, ATP5G3 |
| 3 | Superoxide radicals degradation | 4.07E + 00 | 3.33E − 01 | SOD2, SOD1 |
| 4 | Amyotrophic lateral sclerosis signaling | 4.07E + 00 | 4.12E − 02 | SOD1, BCL2L1, BID, NEFL |
| 5 | Apoptosis signaling | 2.91E + 00 | 3.41E − 02 | BCL2L1, BID, BAK1 |
| 6 | Molecular mechanisms of cancer | 2.78E + 00 | 1.39E − 02 | RHOT2, CDKN2A, BCL2L1, BID, BAK1 |
| 7 | Docosahexaenoic acid (DHA) signaling | 2.40E + 00 | 5.13E − 02 | BCL2L1, BID |
| 8 | Aldosterone signaling in epithelial cells | 2.24E + 00 | 1.99E − 02 | HSPA1A/HSPA1B, HSPD1, HSP90AA1 |
| 9 | Myc mediated apoptosis signaling | 2.07E + 00 | 3.45E − 02 | CDKN2A, BID |
| 10 | PEDF signaling | 1.90E + 00 | 2.82E − 02 | SOD2, BCL2L1 |