Table 3.
Top upstream regulators and target molecules in the regulatory network.
| Upstream regulator | Molecule type | p value of overlap | Target molecules in dataset |
|---|---|---|---|
| RBM5 | Other | 4.25E − 08 | ATP5G3, CDKN2A, HSP90AA1, NDUFV2, UCP2 |
| AIFM1 | Enzyme | 1.43E − 05 | NDUFB6, NDUFS7 |
| DEFB103A/DEFB103B | Other | 1.43E − 05 | BCL2L1, BID |
| BTG2 | Transcription regulator | 1.32E − 04 | SOD1, SOD2 |
| SHC1 | Kinase | 3.10E − 04 | BAK1, BCL2L1 |
| NFE2L2 | Transcription regulator | 4.92E − 04 | SOD1, SOD2 |
| APP | Other | 7.13E − 04 | DNM1L, HSPA1A/HSPA1B |
| RelB | Transcription regulator | 8.83E − 04 | BCL2L1, SOD2 |
| HSF1 | Transcription regulator | 1.21E − 03 | BCL2L1, HSP90AA1, HSPA1A/HSPA1B |
| SOCS1 | Other | 1.99E − 03 | BAK1, BCL2L1 |
| Igm | Complex | 2.13E − 03 | BAK1, CDKN2A |
| IGFBP7 | Transporter | 2.21E − 03 | SOD2 |
| NCF2 | Enzyme | 2.21E − 03 | SOD2 |
| mir-491 | MicroRNA | 2.21E − 03 | BCL2L1 |
| SIRPA | Phosphatase | 2.21E − 03 | BCL2L1 |
| TERT | Enzyme | 2.27E − 03 | CDKN2A, SOD2 |
| FAS | Transmembrane receptor | 2.71E − 03 | BID, SOD2 |
| PPARA | Ligand-dependent nuclear receptor | 2.86E − 03 | CDKN2A, CPT2 |
| IFNG | Cytokine | 4.32E − 03 | BAK1, BCL2L1, HSPA1A/HSPA1B, SOD2 |
| LIN9 | Other | 4.41E − 03 | CDKN2A |
| CASP3 | Peptidase | 4.41E − 03 | BCL2L1 |
| CUL4A | Other | 4.41E − 03 | SOD2 |
| BTG3 | Other | 4.41E − 03 | CDKN2A |
| NOXO1 | Other | 4.41E − 03 | SOD2 |
| CBX8 | Other | 4.41E − 03 | CDKN2A |
| RAC2 | Enzyme | 4.41E − 03 | BCL2L1 |
| PRKACA | Kinase | 4.41E − 03 | CDKN2A |
| NEU2 | Phosphatase | 4.41E − 03 | BCL2L1 |
| S100A11 | Kinase | 4.41E − 03 | HSPA1A/HSPA1B |
| BACH2 | Enzyme | 4.41E − 03 | BCL2L1 |
| CYBA | Other | 4.41E − 03 | CDKN2A |
| CFLAR | Transcription regulator | 4.41E − 03 | CDKN2A |
| NEU2 | Enzyme | 4.41E − 03 | SOD2 |