Table 3.
Effect of naproxen and its metal complexes on the number of entries and time spent in elevated plus maze in acute study.
| Group | Dose (mg/kg) | Observed parameters | ||||
|---|---|---|---|---|---|---|
| Open arm entries | Closed arm entries | Total entries | Time spent in open arms | Time spent in closed arms | ||
| Control | — | 2.3 ± 0.21 | 2.83 ± 0.40 | 5.17 ± 0.47 | 6.83 ± 0.47 | 293.17 ± 0.47 |
| Diazepam | 2 | 5.17 ± 0.54∗∗ | 4.5 ± 0.56∗∗ | 9.67 ± 1.02∗∗ | 17.83 ± 0.94∗∗ | 282.17 ± 0.94∗∗ |
| Naproxen | 25 | 3.17 ± 0.30 | 4.0 ± 0.36 | 7.17 ± 0.54 | 11.67 ± 0.80∗ | 288.33 ± 0.80∗ |
| N-Cu | 25 | 2.83 ± 0.47 | 3.33 ± 0.42 | 7.17 ± 0.47 | 7.67 ± 0.80 | 292.33 ± 0.80 |
| N-Co | 25 | 3.33 ± 0.33 | 3.67 ± 0.33 | 7.0 ± 0.57 | 13.5 ± 0.99∗∗ | 286.5 ± 1.07∗∗ |
| N-Fe | 25 | 1.83 ± 0.30 | 4.0 ± 0.36 | 5.83 ± 0.16 | 4.0 ± 0.63 | 296.0 ± 0.63 |
| N-Ag | 25 | 1.5 ± 0.34 | 3.83 ± 0.33 | 5.17 ± 0.40 | 3.67 ± 0.71 | 296.33 ± 0.71 |
| N-Zn | 25 | 3.17 ± 0.49 | 3.5 ± 0.42 | 6.67 ± 0.60 | 12.67 ± 1.33∗∗ | 287.33 ± 1.33∗∗ |
Each value represents the mean ± SEM, n = 6. ∗ P < 0.01 and ∗∗ P < 0.001 were considered significant compared with control.