Table 5.
Effect of naproxen metal complexes on hypoglycemic property in mice.
| Group | Dose (mg/kg) | Plasma glucose level in mmol/L | |||
|---|---|---|---|---|---|
| 0 hours | 1st hour | 2nd hour | 3rd hour | ||
| Control | — | 5.98 ± 0.28 | 6 ± 0.15 | 5.9 ± 0.19 | 5.75 ± 0.17 |
| Standard | 50 | 6.05 ± 0.18 | 3.78 ± 0.13∗ | 3.6 ± 0.15∗ | 3.43 ± 0.11∗ |
| Naproxen | 25 | 5.72 ± 0.27 | 5.78 ± 0.15 | 5.58 ± 0.10 | 5.73 ± 0.19 |
| Naproxen-copper complex | 25 | 6.15 ± 0.19 | 4.37 ± 0.19∗ | 4.3 ± 0.05∗ | 4.72 ± 0.13∗ |
| Naproxen-cobalt complex | 25 | 5.73 ± 0.18 | 4.7 ± 0.17∗ | 4.5 ± 0.10∗ | 4.6 ± 0.14∗ |
| Naproxen-iron complex | 25 | 5.78 ± 0.22 | 5.58 ± 0.24 | 5.65 ± 0.20 | 5.7 ± 0.19 |
| Naproxen-silver complex | 25 | 5.8 ± 0.24 | 6.03 ± 0.13 | 5.82 ± 0.12 | 5.72 ± 0.18 |
| Naproxen-zinc complex | 25 | 5.22 ± 0.22 | 4.53 ± 0.18∗ | 4.17 ± 0.17∗ | 4.17 ± 0.14∗ |
Each value represents the mean ± SEM, n = 6. ∗ P < 0.001 was considered significant compared with control.