Table 2.
Association of the dichotomized SAI QRST with the all-cause mortality.
| Univariable Cox regression | Multivariable Cox regression | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95 CI | P-value | HR | 95 CI | P-value |
| Age at implant (years) | 1.04 | 1.02–1.07 | <0.001 | 1.03 | 0.99–1.06 | 0.09 |
| Ischemic cardiomyopathy | 12.2 | 1.4–3.4 | 0.001 | 1.4 | 0.71–2.7 | 0.33 |
| Women | 0.61 | 0.34–1.1 | 0.11 | |||
| LVEF (%) | 0.99 | 0.97–1.0 | 0.63 | |||
| QRS duration (ms) | 0.99 | 0.99–1.0 | 0.17 | |||
| Left bundle branch block | 0.75 | 0.51–1.1 | 0.13 | |||
| NYHA class | 2.6 | 1.7–3.9 | <0.001 | 2.4 | 1.4–4.1 | 0.01 |
| S-Creatinine (mg/dL) | 2.0 | 1.5–2.6 | <0.001 | 1.3 | 0.92–1.8 | 0.15 |
| Diabetes mellitus | 11.4 | 0.95–2.0 | 0.09 | |||
| Atrial fibrillation | 1.6 | 1.1–2.4 | 0.01 | 0.88 | 0.51–1.5 | 0.65 |
| Previous stroke / TIA | 2.3 | 0.76–2.2 | 0.35 | |||
| Loop diuretic treatment | 2.2 | 0.90–5.4 | 0.09 | |||
| Beta-blocker | 0.75 | 0.47–1.2 | 0.23 | |||
| ACEi/ARB | 0.31 | 0.18–0.52 | <0.001 | 0.37 | 0.18–0.75 | 0.006 |
| Cardiac resynchronization therapy defibrillator | 0.58 | 0.38–0.90 | 0.01 | 0.82 | 0.45–1.5 | 0.52 |
| SAI QRST <302mV*ms | 1.9 | 1.3–2.8 | 0.001 | 1.8 | 1.0–3.2 | 0.048 |
TIA= transient ischemic attack, ACEi= angiotensin converting enzyme inhibitor, ARB=angiotensin II receptor blocker, NYHA=New York Heart Association classification of heart failure, SAI QRST = sum absolute QRST integral.