Table 2.
Treatment summary
Patient ID | Best overall responseb | Duration of best overall response (months) | Target lesion measurement (mm)a | Site reactions | |||
---|---|---|---|---|---|---|---|
Baseline | 4 wk. post-first injection | 4 wk. post-second injection | First injection | Second injection | |||
UW001 | SD | 8.2c | 33 | 31 | 31 | S | E, S |
UW002 | PD | 23 | 31 | 44 | E, S | E, T | |
UW003 | PD | 20 | 19 | 24 | |||
UW004 | PD | 20 | 22 | 34 | |||
UW005 | PD | 22 | 22 | 32 | P | S | |
UW006 | SD | 7.5c | 9 | 9 | 10 | E | |
UW007 | PD | 9 | 14 | 22 | E, S, P | E, S, T | |
UW008 | PD | 12 | 10 | 10 | E, S | ||
UW009 | PD | 10 | 15 | 15 | S, T | S, T |
There were no Grade 3 or higher treatment-related toxicities. Grade 1 and 2 toxicities were not prospectively collected
There was no clinical autoimmunity and no induction of pathological autoantibodies
PD progressive disease (per RECIST 1.0), SD stable disease (per RECIST 1.0), S swelling, E erythema, T tenderness, P pain
aThe treated tumor lesions were the target lesions
bPatients had a physical examination including evaluation of treated tumor lesions and repeat radiological imaging on Day 57 (±3 business days)
cFrom Day 57 scan