Table 3.
Cox Proportional Hazards for outcome of Amputation
| Univariate Model | Multiple Variable Model | |||
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
|
| ||||
| CKD Stage | ** | |||
| 5 | 4.1 (2.5–6.8) | <0.001 | ||
| 4/3b | 1.6 (0.95–2.6) | 0.08 | ||
| 1/2/3a | 1.0 (reference) | |||
|
| ||||
| Gender | ** | |||
| Female | 1.3 (0.9–2.0) | 0.14 | ||
| Male | 1.0 (reference) | |||
|
| ||||
| Smoking Status | ** | |||
| Current | 0.4 (0.2–0.8) | 0.004 | ||
| Former | 0.5 (0.3–0.8) | 0.005 | ||
| Never | 1.0 (reference) | |||
|
| ||||
| Diabetes | ||||
| Yes | 3.2 (2.0–5.2) | <0.001 | 2.2 (1.3–3.6) | |
| No | 1.0 (reference) | 1.0 (reference) | 0.002 | |
|
| ||||
| Coronary arterial disease | ** | |||
| Yes | 1.5 (0.99–2.4) | 0.06 | ||
| No | 1.0 (reference) | |||
|
| ||||
| TASC Class | ** | |||
| C or D | 1.0 (0.6–1.6) | 0.98 | ||
| A or B | 1.0 (reference) | |||
|
| ||||
| Treatment | ** | |||
| Plain old balloon angioplasty | 1.4 (0.9–2.1) | 0.09 | ||
| Stent | 1.0 (reference) | |||
|
| ||||
| Run-off Score | ||||
| 0 or 1 | 2.4 (1.5–4.0) | <0.001 | 2.0 (1.2–3.4) | 0.01 |
| 2 | 1.3 (0.8–2.1) | <0.001 | 1.2 (0.7–2.1) | 0.43 |
| 3 | 1.0 (reference) | 1.0 (reference) | ||
|
| ||||
| GFR, per 5 units <45 | 1.22 (1.14–1.30) | <0.001 | 1.17 (1.09–1.26) | <0.001 |
**
Variable not retained using backward selection method, alpha-level = 0.05 for retention.