Table 1.
Crude rates of lethal prostate cancer by Gleason grade and combined morphology score among 511 men diagnosed with prostate cancer in Health Professionals Follow-up Studya
| Gleason Grade | Combined morphology score | N | Deaths/Person-years | Crude Rate (95% CI) per 1,000 person-years | 10-year Survival | 20-year Survival |
|---|---|---|---|---|---|---|
| 6 | Group 1: Less angiogenic | 29 | 0/394 | 0 | 100% | 100% |
| Group 2: Moderately angiogenic | 28 | 1/417 | 2.40 (−2.30, 7.11) | 98% | 95% | |
| Group 3: More angiogenic | 26 | 0/453 | 0 | 100% | 100% | |
| 7(3+4) | Group 1: Less angiogenic | 77 | 1/1042 | 0.96 (−0.92, 2.84) | 99% | 98% |
| Group 2: Moderately angiogenic | 58 | 4/842 | 4.75 (0.10, 9.41) | 95% | 90% | |
| Group 3: More angiogenic | 59 | 4/869 | 4.60 (0.09, 9.12) | 95% | 91% | |
| 7(4+3) | Group 1: Less angiogenic | 43 | 1/572 | 1.75 (−1.68, 5.18) | 98% | 97% |
| Group 2: Moderately angiogenic | 51 | 3/681 | 4.41 (−0.58, 9.40) | 96% | 91% | |
| Group 3: More angiogenic | 43 | 16/566 | 28.27 (14.42, 42.12) | 72% | 43% | |
| 8–10 | Group 1: Less angiogenic | 24 | 6/255 | 23.51 (4.70, 42.33) | 76% | 53% |
| Group 2: Moderately angiogenic | 28 | 7/402 | 17.4 (4.51, 30.29) | 83% | 65% | |
| Group 3: More angiogenic | 45 | 19/541 | 35.11 (19.32, 50.90) | 65% | 30% |
a
We categorized vessel irregularity and vessel area into two groups according to the median values. Men were categorized into the more angiogenic group if they had both more irregular vessel lumen and smaller vessel area; men were categorized into the less angiogenic group if they had both less irregular vessel lumen and larger vessel area. The rest of men were grouped into the moderately angiogenic group.