Table 1.
Patient characteristics
| CKD STAGE | 1/2/3a | 3b | 4 | 5 | Total |
|---|---|---|---|---|---|
| Age, mean (SD) | |||||
| Number | 445 | 339 | 220 | 48 | 1052 |
| Age | 70.2 (10.1) | 73.9 (7.8) | 74.4 (7.9) | 72.9 (10.3) | 72.4 (9.2) |
| Follow-up Time | |||||
| Number | 297 | 177 | 79 | 13 | 566 |
| Median (years) | 3.0 | 4.1 | 6.1 | 7.8 | 3.8 |
| Female | 231 (51.9%) | 176 (51.9%) | 100 (45.5 %) | 19 (39.6%) | 526 (50.0%) |
| Male | 214 (48.1%) | 163 (48.1%) | 120 (54.5 %) | 29 (60.4%) | 526 (50.0%) |
| GFR at Baseline | |||||
| Number | 445 | 339 | 220 | 48 | 1052 |
| GFR at baseline | 58.9 (12.6) | 37.2 (4.2) | 23.5 (4.2) | 12.0 (2.0) | 42.4 (17.8) |
| Laterality | |||||
| Missing | 67 (15.1%) | 28 (8.3%) | 2 (0.9%) | 3 (6.3%) | 100 (9.5%) |
| Unilateral | 248 (55.7%) | 184 (54.3%) | 103 (46.8 %) | 27 (56.3%) | 562 (53.4%) |
| Bilateral | 130 (29.2%) | 127 (37.5%) | 115 (52.3 %) | 18 (37.5%) | 390 (37.1%) |
| Peak RI (SD) | 0.7 (0.1) | 0.8 (0.7) | 0.8 (0.1) | 0.8 (0.1) | 0.8 (0.4) |
| Proteinuria | |||||
| Missing | 90 (20.2%) | 64 (18.9%) | 47 (21.4% ) | 9 (18.8%) | 210 (20.0%) |
| Low (AER<300) | 285 (64.0%) | 196 (57.8%) | 91 (41.4% ) | 3 (6.3%) | 575 (54.7%) |
| High (AER>300) | 70 (15.7%) | 79 (23.3%) | 82 (37.3% ) | 36 (75.0%) | 267 (25.4%) |
|
Baseline Blood Pressure Medicati ons |
|||||
| Number | 357 | 317 | 212 | 45 | 931 |
| Mean (SD) | 2.7 (1.4) | 2.8 (1.2) | 3.3 (1.2) | 2.9 (1.3) | 2.9 (1.3) |
| Baseline DBP | |||||
| Number | 290 | 231 | 168 | 38 | 727 |
| Mean (SD) | 78.3 (14.5) | 76.4 (15.2) | 74.4 (14.3 ) | 78.9 (14.4) | 76.8 (14.8) |
| Baseline SBP | |||||
| Number | 291 | 231 | 168 | 38 | 728 |
| Mean (SD) | 157.4 (28.4) | 156.6 (29.2) | 152.7 (27. 7) | 162.0 (26.8 ) | 156.3 (28.5) |
| Smoking Status | |||||
| Missing | 35 (7.9%) | 56 (16.5%) | 53 (24.1% ) | 14 (29.2%) | 158 (15.0%) |
| Never | 4 (0.9%) | 6 (1.8%) | 4 (1.8%) | 1 (2.1%) | 15 (1.4%) |
| Quit | 342 (76.9%) | 209 (61.7%) | 103 (46.8 %) | 19 (39.6%) | 673 (64.0%) |
| Current | 64 (14.4%) | 68 (20.1%) | 60 (27.3% ) | 14 (29.2%) | 206 (19.6%) |
| PAD | |||||
| Missing | 12 (2.7%) | 7 (2.1%) | 1 (0.5%) | 0 (0.0%) | 20 (1.9%) |
| No | 167 (37.5%) | 129 (38.1%) | 95 (43.2% ) | 25 (52.1%) | 416 (39.5%) |
| Yes | 266 (59.8%) | 203 (59.9%) | 124 (56.4 %) | 23 (47.9%) | 616 (58.6%) |
| Carotid Disease | |||||
| Missing | 9 (2.0%) | 2 (0.6%) | 0 (0.0%) | 0 (0.0%) | 11 (1.0%) |
| No | 278 (62.5%) | 178 (52.5%) | 127 (57.7 %) | 31 (64.6%) | 614 (58.4%) |
| Yes | 158 (35.5%) | 159 (46.9%) | 93 (42.3% ) | 17 (35.4%) | 427 (40.6%) |
| Diabetes | |||||
| Missing | 5 (1.1%) | 1 (0.3%) | 0 (0.0%) | 0 (0.0%) | 6 (0.6%) |
| No | 322 (72.4%) | 228 (67.3%) | 136 (61.8%) | 37 (77.1%) | 723 (68.7%) |
| Yes | 118 (26.5%) | 110 (32.4%) | 84 (38.2% ) | 11 (22.9%) | 323 (30.7%) |
|
Coronary arterial disease |
|||||
| Missing | 16 (3.6%) | 3 (0.9%) | 0 (0.0%) | 0 (0.0%) | 19 (1.8%) |
| No | 177 (39.8%) | 123 (36.3%) | 75 (34.1% ) | 13 (27.1%) | 388 (36.9%) |
| Yes | 252 (56.6%) | 213 (62.8%) | 145 (65.9 %) | 35 (72.9%) | 645 (61.3%) |
| Stroke | |||||
| Missing | 9 (2.0%) | 2 (0.6%) | 0 (0.0%) | 0 (0.0%) | 11 (1.0%) |
| No | 353 (79.3%) | 266 (78.5%) | 163 (74.1 %) | 40 (83.3%) | 822 (78.1%) |
| Yes | 83 (18.7%) | 71 (20.9%) | 57 (25.9% ) | 8 (16.7%) | 219 (20.8%) |
| Hypertension | |||||
| Missing | 4 (0.9%) | 3 (0.9%) | 2 (0.9%) | 0 (0.0%) | 9 (0.9%) |
| No | 16 (3.6%) | 4 (1.2%) | 6 (2.7%) | 5 (10.4%) | 31 (2.9%) |
| Yes | 425 (95.5%) | 332 (97.9%) | 212 (96.4 %) | 43 (89.6%) | 1012 (96.2%) |
| Hyperlipidemia | |||||
| Missing | 8 (1.8%) | 2 (0.6%) | 1 (0.5%) | 0 (0.0%) | 11 (1.0%) |
| No | 102 (22.9%) | 57 (16.8%) | 46 (20.9% ) | 14 (29.2%) | 219 (20.8%) |
| Yes | 335 (75.3%) | 280 (82.6%) | 173 (78.6 %) | 34 (70.8%) | 822 (78.1%) |
| Primary endpoint | |||||
| Dialysis | 5 (1.1%) | 25 (7.4%) | 53 (24.1% ) | 22 (45.8%) | 105 (10.0%) |
| Transplant | 0 (0.0%) | 0 (0.0%) | 4 (1.8%) | 2 (4.2%) | 6 (0.6%) |
| Death | 145 (32.6%) | 140 (41.3%) | 96 (43.6% ) | 16 (33.3%) | 397 (37.7%) |
| Censor | 295 (66.3%) | 174 (51.3%) | 67 (30.5%) | 8 (16.7%) | 544 (51.7%) |
|
Status at Last Follow-up |
|||||
| Alive | 297 (66.7%) | 177 (52.2%) | 79 (35.9% ) | 13 (27.1%) | 566 (53.8%) |
| Dead | 148 (33.3%) | 162 (47.8%) | 141 (64.1 %) | 35 (72.9%) | 486 (46.2%) |