Table 2.
Cox Proportional Hazards Models [Progression to renal replacement therapy, (RRT)]
| Univariable | Multivariable | ||||
|---|---|---|---|---|---|
| Risk factors (variables in each factor being compared (detailed counts in Table 1) |
Number of patients with data |
HR (95% CI) |
p-value | HR (95% CI) |
p-value |
| Stage 5 vs. 1/2/3A 4 vs. 1/2/3A 3b vs. 1/2/3A |
1052 |
84.3 (32.0–222.0) 25.0 (10.0–62.4) 6.2 (2.4–16.2) |
<.001 <.001 <.001 |
33.9 (12.3–93.7) 14.4 (5.6–36.7) 3.4 (1.3–9.4) |
<.001 <.001 .02 |
| Diabetes Mellitus (Y vs. N) |
1046 | 1.2 (0.8–1.8) | .38 | ||
| Hypertension (Y vs. N) |
1043 | 0.6 (0.2–1.7) | .37 | ||
| Hyperlipidemia (Y vs. N) |
1041 | 0.9 (0.6–1.4) | .63 | ||
| Carotid Artery Disease (Y vs. N) |
1041 | 1.1 (0.7–1.6) | .73 | ||
| Stroke (Y vs. N) |
1041 | 1.2 (0.8–1.8) | .43 | ||
| Coronary Arterial Disease [CAD, (Y vs. N)] |
1033 | 1.4 (0.9–2.0) | .13 | ||
| Peripheral Arterial Disease (Y vs. N) |
1032 | 1.0 (0.7–1.4) | .85 | ||
| Proteinuria (Y vs. N) |
842 | 8.0 (5.0–13.0) | <.001 | 3.8 (2.3–6.3) | <.001 |
| Family History of CAD (Y vs. N) |
966 | 0.8 (0.6–1.2) | .35 | ||
| Bilateral RAS (vs Unilateral) |
952 | 1.5 (1.0–2.1) | .04 | ||
| Current Smoker (Y vs. N) |
894 | 2.8 (1.8–4.4) | <.001 | ||
| Statin (Y vs. N) |
951 | 1.14 (0.69–1.89) | 0.62 | ||
| ACEi/ARB (Y vs. N) |
951 | 0.67 (0.40–1.11) | 0.12 | 0.57 (0.34–0.95) | 0.03 |
| Calcium Channel Blocker (Y vs. N) |
951 | 1.99 (1.03–3.83) | 0.04 | 2.1 (1.09–4.1) | 0.03 |
| Beta Blocker (Y vs. N) |
951 | 1.0 (0.58 – 1.74) | 1.0 | ||
| Aspirin (Y vs. N) |
951 | 1.29 (0.67–2.49) | 0.45 | ||
| Plavix (Y vs. N) |
951 | 1.0 (0.65–1.54) | 0.99 | ||
| Warfarin (Y vs. N) |
951 | 1.10 (0.72–1.68) | 0.65 | ||
| Insulin (Y vs. N) |
951 | 1.51 (0.98–2.3) | 0.06 | ||
Definitions: HR- hazard ratio, CI- confidence interval