. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: Neurotoxicology. 2016 Jan 23;59:164–174. doi: 10.1016/j.neuro.2016.01.002

Table 3.

Comparison of transsulfuration metabolites in cerebellum of control and TCE-treated mice. Results represent the mean (SD).

Glutathione and cysteine redox status in cerebellum (nmol/mg/protein)	0 mg/ml TCE	0.01 mg/ml TCE	0.1 mg/ml TCE
GSH	17.63 (1.14)	17.23 (0.98)	14.57 (2.17)^*
GSSG	0.45 (0.10)	0.56 (0.20)	0.68 (0.22)
GSH/GSSG ratio	41.03 (11.56)	34.29 (13.67)	23.12 (8.64)^*
Oxidized GSH (%)	5.22 (0.91)	6.15 (2.16)	8.73 (2.58)^*
CyS	2.73 (0.42)	1.43 (0.28)^*	1.51 (0.22)^***
CySSCy	9.71 (1.32)	9.10 (1.55)	8.24 (1.24)
CyS/CySSCy ratio	0.29 (0.08)	0.16 (0.04)^*	0.18 (0.05)^*
Total CyS	22.14 (2.43)	19.63 (3.21)	17.99 (2.51)^*

Total Cysteine (CyS + 2xCySSy) was calculated as described in the Methods section. Results are statistically significant compared to results obtained from controls

p≤0.05,

^**

p≤0.005,

^***

p≤0.0005.