Table 1.

Demographic and clinical characteristics of autopsied SMART subjects with known diabetes status and available neuropathological data

	All subjects (N=2,365)	Diabetes (N=507)	No Diabetes (N=1,858)	P value*
Age at death, years	88.7±6.5	87.8±6.0	89.0±6.6	<0.0001
Female (n [%])	1009 (42.7)	147 (29.0)	862 (46.4)	<0.0001
Education, years	14.1±4.2	13.7±4.2	14.3±4.2	0.002
Hypertension (n [%])	1,600 (67.7)	413 (81.5)	1,187 (63.9)	<0.0001
APOE-ε4 carrier (n [%])	543 (23.0)	103 (20.3)	440 (23.7)	0.12
Last clinical diagnosis (n [%])				0.69
Intact cognition	948 (40.1)	204 (40.2)	744 (40.0)
Mild Cognitive Impairment	473 (20.0)	95 (18.7)	378 (20.3)
Dementia	908 (38.4)	198 (39.1)	710 (38.2)
Other/Unknown	36 (1.5)	10 (2.0)	26 (1.4)
MMSE, 6 years prior to death†	27.0±3.8	27.3±3.0	26.9±4.0	0.20
MMSE, ≤ 2 years of death‡	22.2±8.4	21.9±8.4	22.2±8.4	0.58
Animals, 6 years prior to death§	15.0±5.6	14.8±5.7	15.1±5.6	0.63
Animals, ≤ 2 years of death¶	10.7±6.1	10.1±5.9	10.9±6.1	0.032

^*Comparisons are Diabetes vs. No Diabetes; diabetes is determined by self-report or report of antidiabetes medication use.

^†Diabetes, n=179; No Diabetes, n=746.

^‡Diabetes, n=244; No Diabetes, n=1092.

^§Diabetes, n=200; No Diabetes, n=775.

^¶Diabetes, n=339; No Diabetes, n=1167. Results presented are mean ± standard deviation unless otherwise noted.