Table 3.

Adjusted odds ratios for diabetes given presence of cerebrovascular disease and Alzheimer’s disease neuropathology.

Neuropathology (Dependent variable)	Model 1* OR (95% CI)	Model 2† OR (95% CI)
Cerebrovascular pathology (present vs. absent)
Any infarcts	1.57 (1.23, 2.00)‡§	1.54 (1.19, 2.00)‡§
Large artery infarcts	1.19 (0.94, 1.51)	1.17 (0.92, 1.49)
Lacunes	1.71 (1.39, 2.12)‡§	1.77 (1.42, 2.20)‡§
Microinfarcts	1.17 (0.90, 1.53)	1.16 (0.88, 1.54)
Three infarct types reported	1.44 (1.00, 2.09)	1.48 (1.01, 2.16)‡
Alzheimer’s disease pathology
Braak NFT stage
V/VI vs. 0/I/II	0.82 (0.61, 1.11)	0.97 (0.70, 1.35)
III/IV vs. 0/I/II	0.92 (0.72, 1.18)	0.99 (0.76, 1.29)
CERAD neuritic plaque rating
Frequent vs. None	0.96 (0.68, 1.36)	1.25 (0.83, 1.87)
Moderate vs. None	1.02 (0.78, 1.33)	1.11 (0.83, 1.48)
Sparse vs. None	0.98 (0.73, 1.30)	1.07 (0.79, 1.46)
Modified Alzheimer’s ABC rating
High vs. No AD changes	1.05 (0.76, 1.46)	1.13 (0.77, 1.65)
Intermediate vs. No AD changes	1.17 (0.86, 1.60)	1.34 (0.96, 1.87)
Low vs. No AD changes	1.22 (0.92, 1.60)	1.31 (0.98, 1.76)

^*Odds ratios are adjusted for age at death (centered at 85), female sex (1, 0), and research center (Honolulu-Asia Aging Study, Oregon Health & Science University, Rush University Medical Center, Washington University, or University of Kentucky).

^†In model 2, years of education, history of hypertension (1, 0), and APOE-ε4 carrier status (1, 0) are included as additional control variables.

^‡P value significant at 0.05.

^§P value statistically significant after applying Holm-Bonferroni procedure.