Table 3.
Effect modification of body size and weight gain on the association of FRAP1 rs12125777 genotype with breast cancer1
| European American
|
African American
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | GA/AA | GG | GA/AA | ||||||||
|
|
|
||||||||||
| # Case/Control | OR (ref.) | # Case/Control | OR (95% CI) | P-interaction | # Case/Control | OR (ref.) | # Case/Control | OR (95% CI) | P-interaction | ||
| Body mass index (kg/m2) | <25 | 270/260 | 1.00 | 23/24 | 0.85 (0.45–1.61) | 0.007 | 91/113 | 1.00 | 20/20 | 1.54 (0.72–3.27) | 0.29 |
| 25 – <30 | 145/167 | 1.00 | 17/8 | 2.37 (0.91–6.13) | 134/174 | 1.00 | 37/37 | 1.36 (0.79–2.33) | |||
| ≥30 | 158/167 | 1.00 | 21/4 | 7.69 (2.11–28.0) | 264/323 | 1.00 | 42/57 | 0.87 (0.55–1.39) | |||
| Waist-to-hip ratio | ≤0.85 | 339/353 | 1.00 | 35/25 | 1.28 (0.72–2.26) | 0.15 | 207/260 | 1.00 | 42/53 | 1.03 (0.64–1.64) | 0.57 |
| >0.85 | 234/241 | 1.00 | 26/11 | 2.75 (1.27–5.94) | 282/350 | 1.00 | 57/61 | 1.17 (0.77–1.77) | |||
| Weight gain from age 20 (lb.) | <102 | 134/140 | 1.00 | 13/13 | 1.07 (0.44–2.58) | 0.021 | 49/65 | 1.00 | 10/10 | 1.49 (0.47–4.73) | 0.37 |
| 10 – <25 | 96/87 | 1.00 | 9/8 | 0.96 (0.32–2.92) | 37/51 | 1.00 | 11/9 | 2.13 (0.53–8.51) | |||
| 25 – <35 | 115/118 | 1.00 | 13/7 | 2.22 (0.78–6.35) | 66/109 | 1.00 | 15/21 | 1.26 (0.58–2.77) | |||
| ≥35 | 228/249 | 1.00 | 26/8 | 3.34 (1.42–7.85) | 337/385 | 1.00 | 63/74 | 0.96 (0.65–1.41) | |||
1
Adjusted for age at diagnosis, proportion of European ancestry, education, family history of breast cancer, history of benign breast disease, age at menarche, parity, breastfeeding status, menopausal status, and status of cigarette smoking. Models were further mutually adjusted for the body size and weight gain variables. For example, ORs for BMI were adjusted for WHR and weight gain from age 20.
2
Including no change in weight or weight loss.