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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Addict Biol. 2016 Jan 24;22(3):616–628. doi: 10.1111/adb.12353

Figure 1. Expression of the GABAAR tonic current is developmentally regulated in layer V pyramidal neurons of the PrL-C.

Figure 1

A) Representative trace showing the measurement of tonic current as a change in holding current (Ihold) after bath application of the GABAAR antagonist picrotoxin (100 μM, gray dashed line). B) Phasic (black) and tonic (white) GABAAR currents measured at specific developmental time-points (PD: postnatal day) revealed that the amplitude of both tonic and phasic GABA currents remained stable throughout development. C) Although there was no developmental change in tonic current amplitude, the percentage of cells expressing a tonic current exhibited a dramatic developmental increase (p = 0.002).