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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Addict Biol. 2016 Jan 24;22(3):616–628. doi: 10.1111/adb.12353

Figure 2. Effect of adolescent ethanol exposure on phasic GABAAR currents in layer V pyramidal neurons of the adult PrL-C.

Figure 2

A) Representative traces of IPSCs from adult PrL-C slice obtained from control and AIE exposed rats. Cells were voltage-clamped at -70mV. B) While the frequency was similar in slices from both control and AIE treated rats, spontaneous IPSC (sIPSC) amplitude was significantly reduced in slices from AIE exposed rats (n = 20-21 cells/group; **p = 0.004). C) Representative paired-pulse traces of evoked IPSC (eIPSC) currents from adult PrL-C slices obtained from control and AIE treated rats. D) The paired-pulse ratio (PPR) was not altered by AIE exposure (n = 8-9 cells/group). E) Representative traces of miniature IPSCs (mIPSC) from adult PrL-C slices obtained from control and AIE exposure rats. F) AIE did not alter either the amplitude or frequency of mIPSCs (n = 8-9 cells/group).