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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Addict Biol. 2016 Jan 24;22(3):616–628. doi: 10.1111/adb.12353

Figure 4. Blocking GABA reuptake does not reverse AIE-associated reduction in tonic GABAAR currents.

Figure 4

A) Representative trace showing changes in holding current that occur following bath application of nipecotic acid in slices from the adult PrL-C. After establishing a stable baseline holding current, nipecotic acid (500 μM) was bath applied for 5 minutes. Next, picrotoxin (100 μM) was also added to the bath. The tonic current was measured as the change in Ihold from baseline (gray line) to that observed after picrotoxin. B) AIE exposure resulted in a significant decrease in the amplitude of the GABAAR tonic current amplitude compared to slices from control rats (n = 6-7 cells/group; *p < 0.05).