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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Invest Dermatol. 2016 Mar 16;136(8):1647–1655. doi: 10.1016/j.jid.2016.02.809

Figure 4. Loss of PRC2 results in three distinct skin phenotypes.

Figure 4

Schematic diagram showing how loss of PRC2 affects the development of different skin lineages. Embryonic epidermal progenitors give rise to the epidermis, Merkel cells, and hair follicles. In mice in which either Ezh1/2, EED, or Suz12 are deleted from the epidermal progenitors, there is premature formation of the stratum corneum, an increase in the number of Merkel cells, and defective postnatal hair follicle development due to decreased matrix proliferation and increased apoptosis of the hair follicles.