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. 2016 Jul 25;9:58. doi: 10.3389/fnmol.2016.00058

Figure 6.

Figure 6

Glial fibrillary acidic protein (GFAP) immunoreactivity in blue LED-induced RD retinas. Confocal micrographs taken from vertical sections of the central (left panel) and peripheral (right panel) retina processed for GFAP (red) immunoreactivity in normal (A) and blue LED-induced RD mice (B–E). (A) A representative normal control retina. GFAP was expressed in astrocytes and Müller cell endfeet in the GCL. (B) A representative RD retina immediately after blue LED exposure (0 h). Expression of GFAP was similar to that in the normal control. (C,D) A representative RD retina at 24 h after blue LED exposure. GFAP immunoreactivity was slightly increased relative to 0 h. Thin GFAP-labeled Müller cell processes were found in the INL and the IPL. There were no differences in GFAP expression between the central (C) and peripheral (D) retina at this time point. (E,F) A representative RD retina at 72 h after blue LED exposure. GFAP immunoreactivity was increased in both the central (E) and peripheral (F) retina, particularly in the ONL of the central retina, where GFAP-labeled Müller cell processes (arrowheads) extended to the outer limiting membrane. (G,H) A representative RD retina at 120 h after blue LED exposure. GFAP immunoreactivity was decreased in both the central (G) and peripheral (H) retina, but GFAP-labeling (arrowheads) persisted in the outer limiting membrane.