Table 1.
Main studies suggesting a cut-off value for α-fetoprotein when selecting candidates for liver transplantation
| Ref. | Year | No. of patients | Country | Study design | AFP cut-off value | Endpoint |
| Yamashiki et al[43] | 2004 | 93 | United States | Prospective | 100 ng/mL | Drop-out from list |
| Shetty et al[42] | 2004 | 109 | United States | Retrospective | 300 ng/mL | Recurrence, death |
| Todo et al[54] | 2007 | 653 | Japan | Retrospective | 200 ng/mL | Recurrence |
| 1000 ng/mL | ||||||
| Parfitt et al[61] | 2007 | 75 | Canada | Retrospective | 1000 ng/mL | Recurrence |
| Pérez-Saborido et al[44] | 2007 | 95 | Spain | Retrospective | 200 ng/mL | Recurrence |
| Onaca et al[10] | 2007 | 902 | United States | Retrospective | 200 ng/mL | Recurrence |
| Adler et al[86] | 2008 | 226 | Belgium | Retrospective | 100 ng/mL | Recurrence |
| Zou et al[45] | 2008 | 303 | China | Retrospective | 1000 ng/mL | Fatal recurrence |
| Ioannou et al[50] | 2008 | 5028 | United States | Retrospective | 455 ng/mL | Death |
| Xu et al[46] | 2009 | 97 | China | Retrospective | 400 ng/mL | Recurrence |
| Toso et al[49] | 2009 | 6478 | Canada | Retrospective | 400 ng/mL | Death |
| Lao et al[55] | 2009 | 124 | United States | Prospective | 1000 ng/mL | Recurrence |
| Xiao et al[87] | 2009 | 224 | China | Retrospective | 800 ng/mL | Death |
| McHugh et al[47] | 2010 | 101 | United States | Retrospective | 100 ng/mL | Recurrence, death |
| Levi et al[88] | 2010 | 244 | United States | Retrospective | 100 ng/mL | Recurrence |
| Merani et al[66] | 2011 | 6817 | United States | Retrospective | 400 ng/mL | Death |
| Lai et al[89] | 2011 | 153 | Italy | Retrospective | 210 ng/mL | Recurrence |
| Mailey et al[48] | 2011 | 2253 | United States | Retrospective | 400 ng/mL | Death |
| Muscari et al[28] | 2012 | 122 | France | Retrospective | 500 ng/mL | Recurrence, death |
| Ciccarelli et al[65] | 2012 | 137 | Belgium | Retrospective | 400 ng/mL | Recurrence |
| Wong et al[59] | 2013 | 211 | United States | Retrospective | 400 ng/mL | Recurrence |
| Harimoto et al[90] | 2013 | 167 | Japan | Retrospective | 300 ng/mL | Recurrence |
| Abdel-Wahab et al[68] | 2013 | 170 | Egypt | Retrospective | 200 ng/mL | Recurrence, death |
| Grąt et al[67] | 2014 | 121 | Poland | Retrospective | 100 ng/mL | Recurrence |
| Hameed et al[30] | 2014 | 211 | United States | Retrospective | 1000 ng/mL | Microvascular invasion |
| Lee et al[91] | 2014 | 69 | South Korea | Retrospective | 200 ng/mL | Recurrence |
| Grąt et al[92] | 2016 | 146 | Poland | Retrospective | 100 ng/mL | Recurrence |
AFP: Alpha-fetoprotein.