Table 2.

International Club of Ascites new definitions for the diagnosis and management of acute kidney injury in patients with cirrhosis[68]

Baseline sCr	A value of sCr obtained in the previous 3 mo, when available, can be used as baseline sCr. In patients with more than one value within the previous 3 mo, the value closest to the admission time to the hospital should be used. In patients without a previous sCr value, the sCr on admission should be used as baseline
Definition of AKI	Increase in sCr ≥ 0.3 mg/dL (≥ 26.5 mmol/L) within 48 h; or a percentage increase sCr ≥ 50% from baseline which is known, or presumed, to have occurred within the prior 7 d
Staging of AKI	Stage 1: Increase in sCr ≥ 0.3 mg/dL (26.5 mmol/L) or an increase in sCr ≥ 1.5-fold to twofold from baseline Stage 2: Increase in sCr > two to threefold from baseline Stage 3: Increase of sCr > threefold from baseline or sCr ≥ 4.0 mg/dL (353.6 mmol/L) with an acute increase ≥ 0.3 mg/dL (26.5 mmol/L) or initiation of renal replacement therapy
Progression of AKI	Progression: Progression of AKI to a higher stage and/or need for RRT
	Regression: Regression of AKI to a lower stage
Response to treatment	No response: No regression of AKI
	Partial response: Regression of AKI stage with a reduction of sCr to ≥ 0.3 mg/dL (26.5 mmol/L) above the baseline value
	Full response: Return of sCr to a value within 0.3 mg/dL (26.5 mmol/L) of the baseline value

AKI: Acute kidney injury; RRT: Renal replacement therapy; sCr: Serum creatinine.