Table 4. Outcomes variables by group (depressive vs. non-depressive at 1st trimester) at second (20 weeks) and third (34 weeks) trimester.
| Outcomes | Group | N | 20 weeks of gestation | 34 weeks of gestation | P value (group) | P value (time) | P value (interaction) |
|---|---|---|---|---|---|---|---|
| Hemodynamic | |||||||
| SBP (mmHg) | Non-depressive | 34 | 109±8 | 112±14 | 0.571 | 0.911 | 0.292 |
| Depressive | 10 | 110±14 | 108±9 | — | — | — | |
| DBP (mmHg) | Non-depressive | 33 | 64±8 | 66±11 | 0.727 | 0.622 | 0.656 |
| Depressive | 10 | 64±10 | 64±8 | — | — | — | |
| HR (beats·min−1) | Non-depressive | 41 | 79±9 | 83±12 | 0.855 | 0.469 | 0.078 |
| Depressive | 11 | 81±16 | 80±13 | — | — | — | |
| SV (mL·beat−1) | Non-depressive | 42 | 57±12 | 53±12 | 0.069 | 0.068 | 0.069 |
| Depressive | 12 | 56±14 | 56±12 | — | — | — | |
| CO (mL·min−1) | Non-depressive | 42 | 4,447±1,037 | 4,302±879 | 0.567 | 0.168 | 0.898 |
| Depressive | 11 | 4,654±1,162 | 4,478±879 | — | — | — | |
| CO index (mL·min−1·m−2) | Non-depressive | 40 | 2,611±575 | 2,439±638 | — | — | — |
| Depressive | 9 | 2,512±693 | 2,368±410 | 0.717 | 0.061 | 0.769 | |
| TVR (dynes·s·cm−5) | Non-depressive | 40 | 1,508±375 | 1,590±477 | 0.577 | 0.378 | 0.580 |
| Depressive | 11 | 1,473±366 | 1,494±283 | — | — | — | |
| Cardiac remodeling | |||||||
| LA area (mm) | Non-depressive | 44 | 18±3 | 17±3 | 0.839 | 0.180 | 0.985 |
| Depressive | 15 | 18±3 | 17±2 | — | — | — | |
| LA volume (mm3) | Non-depressive | 44 | 51±13 | 48±12 | 0.708 | 0.130 | 0.838 |
| Depressive | 15 | 50±14 | 47±11 | — | — | — | |
| LVDD (mm) | Non-depressive | 43 | 46±4 | 47±5 | 0.275 | 0.342 | 0.645 |
| Depressive | 15 | 44±7 | 45±6 | — | — | — | |
| LVSD (mm) | Non-depressive | 43 | 28±3 | 28±4 | 0.042 | 0.335 | 0.789 |
| Depressive | 15 | 26±3 | 27±4 | — | — | — | |
| IVST (mm) | Non-depressive | 44 | 8±1 | 0.84±0.16 | 0.079 | 0.138 | 0.138 |
| Depressive | 15 | 9±1 | 9±1 | — | — | — | |
| PWT (mm) | Non-depressive | 44 | 8±2 | 9±2 | 0.100 | 0.049 | 0.673 |
| Depressive | 15 | 9±2 | 9±2 | — | — | — | |
| PWTs (mm) | Non-depressive | 44 | 14±3 | 15±3 | 0.638 | 0.161 | 0.894 |
| Depressive | 14 | 14±2 | 15±2 | — | — | — | |
| RWT (mm) | Non-depressive | 43 | 3±1 | 4±1 | 0.022 | 0.285 | 0.255 |
| Depressive | 15 | 4±1 | 4±1 | — | — | — | |
| LVM (g) | Non-depressive | 43 | 118±29 | 131±36 | 0.424 | 0.008 | 0.453 |
| Depressive | 15 | 128±41 | 136±38 | — | — | — | |
| LVMI (g·m−2) | Non-depressive | 41 | 67±16 | 73±20 | 0.957 | 0.019 | 0.618 |
| Depressive | 13 | 69±16 | 73±16 | — | — | — | |
| cESS (kdynes·cm−2) | Non-depressive | 40 | 104±28 | 104±29 | 0.293 | 0.539 | 0.554 |
| Depressive | 12 | 98±21 | 93±20 | — | — | — | |
| LV function | |||||||
| LVEF (%) | Non-depressive | 42 | 70±6 | 69±6 | 0.009 | 0.876 | 0.752 |
| Depressive | 15 | 74±4 | 74±4 | — | — | — | |
| FS (%) | Non-depressive | 43 | 39±6 | 39±5 | 0.102 | 0.974 | 0.845 |
| Depressive | 15 | 41±5 | 41±6 | — | — | — | |
| E (m·s−1) | Non-depressive | 42 | 93±17 | 84±19 | 0.984 | 0.017 | 0.374 |
| Depressive | 13 | 90±23 | 86±16 | — | — | — | |
| A (m·s−1) | Non-depressive | 42 | 56±12 | 62±14 | 0.821 | 0.210 | 0.210 |
| Depressive | 13 | 60±18 | 60±13 | — | — | — | |
| E/A | Non-depressive | 42 | 1.7±0.4 | 1.4±0.4 | 0.826 | 0.002* | 0.118 |
| Depressive | 13 | 1.5±0.7 | 1.4±0.5 | — | — | — | |
| DT (ms) | Non-depressive | 41 | 144±35 | 135±38 | 0.664 | 0.291 | 0.686 |
| Depressive | 13 | 137±50 | 133±49 | — | — | — | |
| IVRT (ms) | Non-depressive | 36 | 71±15 | 76±19 | 0.210 | 0.315 | 0.474 |
| Depressive | 11 | 79±11 | 80±12 | — | — | — | |
Threshold P value set at 0.002 [i.e., 0.05 divided by the number of outcomes in these analyses (n=27)]. *, P<0.002. A, atrial filling velocity; cESS, wall stress; CO, cardiac output; CO, index, cardiac output index; DBP, diastolic blood pressure; DT, deceleration time of E wave; E, early filling velocity; FS, fractional shortening; HR, heart rate; IVRT: isovolumetric relaxation time; IVST, interventricular septal thickness; LA, left atrial; LV, left ventricular; LVDD, LV diastolic diameter; LVEF, LV ejection fraction; LVM, LV mass; LVMI, LV mass index; LVSD, LV systolic diameter; PWT, posterior wall thickness; PWTs, posterior wall thickness at systole; RWT, relative wall thickness; SBP, systolic blood pressure; SV, stroke volume; TVR, total vascular resistance.