Table 5. Outcomes variables by group (depressive vs. non-depressive at third trimester) at second (20 weeks) and third (34 weeks) trimester.
| Outcomes | Group | N | 20 weeks of gestation | 34 weeks of gestation | P value (group) | P value (time) | P value (interaction) |
|---|---|---|---|---|---|---|---|
| Hemodynamic | |||||||
| SBP (mmHg) | Non-depressive | 31 | 109±9 | 113±14 | 0.412 | 0.942 | 0.096 |
| Depressive | 13 | 110±11 | 107±8 | — | — | — | |
| DBP (mmHg) | Non-depressive | 31 | 64±8 | 65±12 | 0.788 | 0.547 | 0.695 |
| Depressive | 12 | 65±9 | 65±7 | — | — | — | |
| HR (beats·min−1) | Non-depressive | 39 | 79±10 | 82±12 | 0.535 | 0.140 | 0.515 |
| Depressive | 12 | 82±14 | 83±15 | — | — | — | |
| SV (mL·beat−1) | Non-depressive | 38 | 56±13 | 53±12 | 0.247 | 0.009 | 0.320 |
| Depressive | 16 | 59±13 | 57±11 | — | — | — | |
| CO (mL·min−1) | Non-depressive | 38 | 4,389±1,073 | 4,236±1,004 | 0.228 | 0.148 | 0.997 |
| Depressive | 15 | 4,749±999 | 4,598±1,005 | — | — | — | |
| CO index (mL·min−1·m−2) | Non-depressive | 35 | 2,558±640 | 2,380±648 | 0.412 | 0.026 | 0.716 |
| Depressive | 14 | 2,680±457 | 2,551±456 | — | — | — | |
| TVR (dynes·s·cm−5) | Non-depressive | 37 | 1,377±354 | 1,631±481 | 0.209 | 0.378 | 0.348 |
| Depressive | 14 | 1,435±354 | 1,432±289 | — | — | — | |
| Cardiac remodeling | |||||||
| LA area (mm) | Non-depressive | 43 | 18±3 | 17±3 | 0.149 | 0.314 | 0.425 |
| Depressive | 16 | 17±2 | 17±2 | — | — | — | |
| LA volume (mm3) | Non-depressive | 43 | 52±14 | 49±12 | 0.210 | 0.265 | 0.452 |
| Depressive | 16 | 47±11 | 46±11 | — | — | — | |
| LVDD (mm) | Non-depressive | 42 | 45±5 | 46±5 | 0.312 | 0.922 | 0.143 |
| Depressive | 16 | 47±4 | 47±5 | — | — | — | |
| LVSD (mm) | Non-depressive | 42 | 27±3 | 28±4 | 0.414 | 0.186 | 0.296 |
| Depressive | 16 | 28±3 | 29±3 | — | — | — | |
| IVST (mm) | Non-depressive | 43 | 8±2 | 8±2 | 0.452 | 0.003 | 0.098 |
| Depressive | 16 | 8±1 | 9±2 | — | — | — | |
| PWT (mm) | Non-depressive | 43 | 8±2 | 9±2 | 0.382 | 0.008 | 0.294 |
| Depressive | 16 | 8±2 | 9±2 | — | — | — | |
| PWTs (mm) | Non-depressive | 42 | 14±3 | 15±3 | 0.931 | 0.049 | 0.198 |
| Depressive | 16 | 14±3 | 16±2 | — | — | — | |
| RWT (mm) | Non-depressive | 42 | 37±8 | 37±8 | 0.831 | 0.009 | 0.034 |
| Depressive | 16 | 35±8 | 40±10 | — | — | — | |
| LVM (g) | Non-depressive | 42 | 118±33 | 128±37 | 0.209 | 0.001* | 0.578 |
| Depressive | 16 | 128±31 | 142±32 | — | — | — | |
| LVMI (g·m−2) | Non-depressive | 39 | 67±16 | 72±20 | 0.400 | 0.005 | 0.760 |
| Depressive | 15 | 70±15 | 77±16 | — | — | — | |
| cESS (kdynes·cm−2) | Non-depressive | 36 | 101±25 | 104±15 | 0.730 | 0.365 | 0.137 |
| Depressive | 16 | 105±30 | 95±32 | — | — | — | |
| LV function | |||||||
| LVEF (%) | Non-depressive | 39 | 70±6 | 70±6 | 0.522 | 0.286 | 0.090 |
| Depressive | 16 | 72±6 | 70±6 | — | — | — | |
| FS (%) | Non-depressive | 42 | 39±5 | 40±5 | 0.953 | 0.255 | 0.019 |
| Depressive | 16 | 41±5 | 38±6 | — | — | — | |
| E (m·s−1) | Non-depressive | 39 | 92±15 | 83±16 | 0.711 | 0.007 | 0.417 |
| Depressive | 16 | 92±25 | 87±23 | — | — | — | |
| A (m·s−1) | Non-depressive | 39 | 56±12 | 61±12 | 0.315 | 0.073 | 0.606 |
| Depressive | 16 | 60±15 | 63±17 | — | — | — | |
| E/A | Non-depressive | 39 | 1.6±0.5 | 1.4±0.4 | 0.627 | <0.001* | 0.312 |
| Depressive | 16 | 1.5±0.6 | 1.4±0.4 | — | — | — | |
| DT (ms) | Non-depressive | 38 | 143±38 | 136±38 | 0.724 | 0.163 | 0.898 |
| Depressive | 16 | 140±44 | 132±47 | — | — | — | |
| IVRT (ms) | Non-depressive | 32 | 74±16 | 79±19 | 0.310 | 0.206 | 0.479 |
| Depressive | 15 | 71±11 | 73±14 | — | — | — | |
Threshold P value set at 0.002 [i.e., 0.05 divided by the number of outcomes in these analyses (n=27)]. *, P<0.002. A, atrial filling velocity; cESS, wall stress; CO, cardiac output; CO, index, cardiac output index; DBP, diastolic blood pressure; DT, deceleration time of E wave; E, early filling velocity; FS, fractional shortening; HR, heart rate; IVRT: isovolumetric relaxation time; IVST, interventricular septal thickness; LA, left atrial; LV, left ventricular; LVDD, LV diastolic diameter; LVEF, LV ejection fraction; LVM, LV mass; LVMI, LV mass index; LVSD, LV systolic diameter; PWT, posterior wall thickness; PWTs, posterior wall thickness at systole; RWT, relative wall thickness; SBP, systolic blood pressure; SV, stroke volume; TVR, total vascular resistance.