Table 1.
Description of the source populations, numbers of cases and designs of TMAs used in this study
| Study acronym | Country | Cases (N) | Age at diagnosis mean (range) | TMAs | Cores per case | Cores per TMA | Core size (mm) | Total cores per study |
|---|---|---|---|---|---|---|---|---|
| ABCS | Netherlands | 892 | 43 (19–50) | 24 | 1–6 | 15–328 | 0.6 | 2,449 |
| CNIO | Spain | 164 | 60 (35–81) | 4 | 1–2 | 80–133 | 1.0 | 316 |
| ESTHER | Germany | 258 | 62 (50–75) | 6 | 1–2 | 78–91 | 0.6 | 461 |
| KBCP | Finland | 276 | 59 (30–92) | 12 | 1–3 | 63–94 | 1.0 | 724 |
| MARIE | Germany | 808 | 62 (50–75) | 27 | 1–5 | 32–92 | 0.6 | 1,490 |
| MCBCS | USA | 491 | 58 (22–87) | 7 | 1–8 | 131–301 | 0.6 | 1,630 |
| ORIGO | Netherlands | 383 | 53 (22–87) | 9 | 1–9 | 67–223 | 0.6 | 991 |
| PBCS | Poland | 1,236 | 56 (27–75) | 22 | 1–2 | 66–145 | 1.0 | 2,358 |
| POSH | UK | 73 | 36 (27–41) | 5 | 1–5 | 75–114 | 0.6 | 194 |
| RBCS | Netherlands | 234 | 45 (25–84) | 6 | 1–5 | 134–199 | 0.6 | 642 |
| SEARCH | UK | 3,528 | 52 (24–70) | 24 | 1–3 | 120–167 | 0.6 | 4,037 |
| UKBGS | UK | 367 | 56 (24–84) | 14 | 1–4 | 62–114 | 1.0 | 1,130 |
| kConFab | Australia | 349 | 45 (20–77) | 6 | 1–2 | 65–114 | 0.6 | 531 |
| Totals | 9,059 | 56 (19–92) | 166 | 1–9 | 15–328 | 0.6–1.0 | 16,953 |