Table 2. Statistical characteristics of the included studies1.
| Authors [year] | BPF | COPD | OR with 95% CI | P value | Extraction | Analysis | Attitude | Adjusted confounding factors (by multivariate analysis) | |
|---|---|---|---|---|---|---|---|---|---|
| COPD (+) | COPD (−) | ||||||||
| Algar et al. [2001] (21) | BPF (+) | 11 (8.7%) | 2 (1.7%) | 7.95 (1.25–50.79) | 0.0283 | Reported | Multivariate | Positive | Age, smoking, BMI, routine blood indexes, steroid use, PFT, albumin, NT, operative modes, sides and time, bronchial closure and coverage, MV |
| BPF (−) | 116 | 113 | |||||||
| Hu et al. [2013] (22) | BPF (+) | 14 (5.8%) | 16 (3.6%) | 1.66 (0.79–3.46) | 0.17 | DDE | Univariate | Negative | NI |
| BPF (−) | 226 | 428 | |||||||
| Lindner et al. [2010] (23) | BPF (+) | 4 (3.9%) | 9 (6.4%) | 0.59 (0.18–1.97) | 0.64 | DDE | Univariate | Negative | NI |
| BPF (−) | 99 | 131 | |||||||
| Panagopoulos et al. [2009] (24) | BPF (+) | 0 (0.0%) | 5 (2.6%) | 0.60 (0.03–11.05) | 1.0 | DDE | Univariate | Negative | NI |
| BPF (−) | 28 | 186 | |||||||
| Sekine et al. [2002] (2) | BPF (+) | 3 (3.8%) | 2 (1.2%) | 3.28 (0.54–20.04) | 0.17 | DDE | Univariate | Negative | NI |
| BPF (−) | 75 | 164 | |||||||
| Sekine et al. [2013] (6) | BPF (+) | 8 (2.2%) | 19 (1.7%) | 1.28 (0.56–2.95) | 0.56 | DDE | Univariate | Negative | NI |
| BPF (−) | 355 | 1079 | |||||||
| Stolz et al. [2014] (25) | BPF (+) | Not available | 4.10 (1.60–9.50) | 0.065 | Reported | Multivariate | Negative | Age, gender, BMI, smoking, NT, coronary artery diseases, hypertension, diabetes, operative modes and sides | |
| BPF (−) | |||||||||
| Yena et al. [2006] (26) | BPF (+) | 19 (15.2%) | 39 (6.5%) | 2.55 (1.38–4.72) | 0.003 | Reported | Multivariate | Positive | Age, gender, smoking, PFT, previous malignancy, diabetes, operative modes, sides and time, bronchial closure and reinforcement |
| BPF (−) | 106 | 561 | |||||||
1, numbers in parentheses indicate the incidence of BPF in patients with COPD and without COPD. BMI, body mass index; BPF, bronchopleural fistula; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DDE, demographic data extrapolated; MV, mechanical ventilation; NI, no information; NT, neo-adjuvant therapy; OR, odds ratio; PFT, pulmonary function test.