Table S4. Baseline characteristics of included studies.

Authors [year] (Ref.)	Language	Origin	Study design	Study period	NOS	Categories			No. samples			Mean age (years)	Histological subtypes			Stages	Material	Detection	Positive site	Cut-off value	Outcomes	Extractions	Analysis	Endpoint	Follow-up (months)
						CP features	Prognosis		Total	PE	NE		AC	SCC	Others
Chen et al. [2013] (18)	English	Taiwan	ROS	2004–2009	8	×	√		20	18	2	70.4	20	–	–	III–IV	Paraffin embedded tissue	IHC	NI	10% staining	HR	Reported	U	OS	60
Chen et al. [2012] (13)	English	China mainland	ROS	2003–2004	8	√	√		113	57	56	57.2	58	52	3	I–IV	Paraffin embedded tissue	IHC	Nucleus	Median histoscore	OR, HR	DDE	U	OS	60
Chiou et al. [2010] (19)	English	Taiwan	ROS	NI	7	×	√		118	78	40	58.8	118	–	–	I–IV	Paraffin embedded tissue	IHC	NI	NI	HR	DDE	U	OS	80
Dong et al. [2013] (33)	Chinese	China mainland	ROS	2009–2012	7	√	×		60	37	23	68.0	17	43	–	I–IV	Paraffin embedded tissue	IHC	Nucleus	25% staining	OR	DDE	U	–	–
Li et al. [2016] (14]	English	China mainland	ROS	2013–2014	7	√	×		65	38	27	53.0	NI	NI	NI	I–IV	Paraffin embedded tissue	IHC	Membrane	25% staining	OR	DDE	U	–	–
Li et al. [2012] (15)	English	China mainland	ROS	2008–2011	7	√	√		44	24	20	62.6	23	21	–	I–IV	Paraffin embedded tissue	IHC	Nucleus	10% staining	OR, HR	DDE	U	OS	12
Li et al. [2013] (16)	English	China mainland	ROS	2004–2007	8	√	√		102	29	73	NI	60	42	–	I–IV	Paraffin embedded tissue	IHC	Nucleus	25% staining	OR, HR	DDE	U	OS	60
Ni et al. [2012] (34)	Chinese	China mainland	ROS	2007–2009	7	√	×		50	21	29	53.0	18	29	3	I–IV	Paraffin embedded tissue	IHC	Nucleus	20% staining	OR	DDE	U	–	–
Qiao et al. [2012] (35)	Chinese	China mainland	ROS	2003–2009	7	√	×		40	15	25	NI	19	21	–	I–III	Paraffin embedded tissue	IHC	Nucleus	5% staining	OR	DDE	U	–	–
Sun et al. [2012] (36)	Chinese	China mainland	ROS	2008–2010	6	√	×		186	87	99	55.0	81	105	–	I–IV	Paraffin embedded tissue	IHC	Cytoplasm	NI	OR	DDE	U	–	–
Tang et al. [2015] (17)	English	Taiwan	ROS	NI	9	√	√		133	92	41	NI	97	22	14	I–IV	Paraffin embedded tissue	IHC	NI	50% staining	OR, HR	DDE, reported	U & M	OS	120
Wei et al. [2011] (37)	Chinese	China mainland	ROS	2002–2005	8	×	√		51	27	24	55.0	NI	NI	NI	I–IV	Paraffin embedded tissue	IHC	Nucleus	0% staining	HR	DDE	U	OS	98
Xiang et al. [2015] (38)	Chinese	China mainland	ROS	2010–2013	7	√	×		60	43	17	53.9	20	30	10	I–IV	Paraffin embedded tissue	IHC	Nucleus	50% staining	OR	DDE	U	–	–
Yang et al. [2014] (39)	Chinese	China mainland	ROS	2008–2013	7	√	×		60	36	24	61.0	23	37	–	I–IV	Paraffin embedded tissue	IHC	NI	10% staining	OR	DDE	U	–	–
Zhang et al. [2013] (40)	Chinese	China mainland	ROS	2005–2006	9	√	√		126	52	74	NI	NI	NI	NI	I–IV	Paraffin embedded tissue	IHC	NI	1% staining	OR, HR	DDE, reported	U & M	OS	90
Zhou et al. [2011] (41)	Chinese	China mainland	ROS	2000–2010	6	√	×		135	44	91	60.0	70	49	16	I–IV	Paraffin embedded tissue	IHC	Nucleus	NI	OR	DDE	U	–	–

AC, adenocarcinoma; CP, clinicopathological; DDE, demographic data extrapolated; HR, hazard ratio; IHC, immunohistochemistry; M, multivariate; NE, negative expression; NI, no information; OR, odds ratio; OS, overall survival; PE, positive expression; ROS, retrospective observational study; U, univariate.