Table 3. Diagnostic validity of plasma markers in differentiating case and control group.

Variables	AUROC (95% CI)	P value	Cut-off values	Sensitivity	Specificity	Youden’s index	PPV	NPV	Accuracy
CYFRA21-1	0.624 (0.519, 0.728)	0.0210	6.595	0.576	0.797	0.373	0.739	0.653	0.686
MicroRNA-210	0.751 (0.661, 0.842)	<0.0001	3.341	0.746	0.746	0.492	0.746	0.746	0.746
MicroRNA-486	0.848 (0.775, 0.922)	<0.0001	1.988	0.831	0.780	0.611	0.790	0.821	0.805

AUROC, the areas under the ROC curves; PPV, the positive predictive value; NPV, the negative predictive value.