Table 1. Clinical characteristics of patients with pure ground-glass opacity nodules, according to pathologic classification.
| Variables | AIS/MIA | IA (n=17) | P valuea | ||
|---|---|---|---|---|---|
| AIS (n=29) | MIA (n=37) | Total (n=66) | |||
| Age (years) | 56.3±12.2 | 59.7±9.7 | 58.2±10.9 | 59.0±10.6 | 0.790 |
| Sex | 0.844 | ||||
| Male | 11 (37.9) | 14 (37.8) | 25 (37.9) | 6 (35.3) | |
| Female | 18 (62.1) | 23 (62.2) | 41 (62.1) | 11 (64.7) | |
| Smoking history | 0.221 | ||||
| Never | 22 (75.9) | 27 (73.0) | 49 (74.2) | 15 (88.2) | |
| Current or former | 7 (24.1) | 10 (27.0) | 17 (25.8) | 2 (11.8) | |
| Interval to surgery (days) | 13.3±13.0 | 17.2±16.5 | 15.5±15.1 | 11.2±11.4 | 0.280 |
| Pulmonary function | |||||
| FEV1 (%) | 92.7±15.5 | 93.7±16.6 | 93.3±16.0 | 97.1±16.8 | 0.416 |
| DLCO (%) | 82.3±13.4 | 86.3±14.8 | 84.6±14.3 | 90.2±14.2 | 0.181 |
| Serum CEA level (ng/mL) | 1.3±1.1 | 1.7±2.0 | 1.6±1.7 | 1.4±0.6 | 0.607 |
| SUVmax | 0.1±0.3 | 0.7±0.9 | 0.4±0.7 | 0.9±1.1 | 0.087 |
| Radiologic features | |||||
| Tumor location | 0.574 | ||||
| Central | 0 | 2 (5.4) | 2 (3.0) | 1 (5.9) | |
| Peripheral | 29 (100.0) | 35 (94.6) | 64 (97.0) | 16 (94.1) | |
| Involved lobe | 0.654 | ||||
| Right upper | 11 (37.9) | 16 (43.2) | 27 (40.9) | 5 (29.4) | |
| Right middle | 1 (3.4) | 3 (8.1) | 4 (6.1) | 0 | |
| Right lower | 6 (20.7) | 4 (10.8) | 10 (15.2) | 3 (17.6) | |
| Left upper | 6 (20.7) | 9 (24.3) | 15 (22.7) | 6 (35.3) | |
| Left lower | 5 (17.2) | 5 (13.5) | 10 (15.2) | 3 (17.6) | |
| GGO size | 1.1±0.4 | 1.4±0.5 | 1.2±0.5 | 1.9±0.6 | <0.001 |
| Pleural retraction | 2 (6.9) | 8 (21.6) | 10 (15.2) | 13 (76.5) | <0.001 |
| Multiple GGO lesions | 9 (31.0) | 5 (13.5) | 14 (21.2) | 2 (11.8) | 0.379 |
Data are shown as mean ± standard deviation or N (%). a, comparison between AIS/MIA and IA. AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma; surgery delay, delay between CT to surgery; FEV1, forced expiratory volume in 1 second; DLCO, diffusing capacity for carbon monoxide; CEA, carcinoembryonic antigen; SUVmax, maximum standardized uptake value; GGO, ground glass opacity.