Table 2. Surgical and pathological characteristics of patients with pure ground-glass opacity nodules, according to pathologic classification.
| Variables | AIS/MIA | IA | P valuea | ||
|---|---|---|---|---|---|
| AIS | MIA | Total | |||
| Surgical | |||||
| Operation type | 0.463 | ||||
| Wedge resection | 16 (55.2) | 8 (21.6) | 24 (36.4) | 4 (23.5) | |
| Segmentectomy | 6 (20.7) | 8 (21.6) | 14 (21.2) | 3 (17.7) | |
| Lobectomy | 7 (24.1) | 21 (56.8) | 28 (42.4) | 10 (58.8) | |
| VATS | 24 (82.8) | 35 (94.6) | 59 (89.4) | 15 (88.2) | 0.891 |
| Open thoracotomy | 5 (17.2) | 2 (5.4) | 7 (10.6) | 2 (11.8) | |
| Pleural adhesion | 8 (27.6) | 6 (16.2) | 14 (21.2) | 3 (17.6) | 0.745 |
| Pathological | |||||
| Tumor size (cm) | 1.0±0.4 | 1.3±0.5 | 1.2±0.5 | 1.8±0.6 | <0.001 |
| Grade | <0.001 | ||||
| Well differentiated | 29 (100.0) | 36 (97.3) | 65 (98.5) | 13 (76.5) | |
| Moderately differentiated | 0 | 0 | 0 | 4 (23.5) | |
| Poorly differentiated | 0 | 1 (2.7) | 1 (1.5) | 0 | |
| Visceral pleural invasion | 0 | 0 | 0 | 0 | |
| Lymphatic invasion | 0 | 0 | 0 | 2 (11.8) | 0.042 |
| Vascular invasion | 0 | 0 | 0 | 1 (5.9) | 0.051 |
| EGFR mutation | 9/14 (64.3) | 14/28 (50.0) | 23/42 (54.8) | 8/14 (57.1) | 0.877 |
| ALK mutation | 1/9 (11.1) | 0/25 (0) | 1/34 (2.9) | 0/13 (0) | 0.532 |
Data are shown as median ± standard deviation or N (%). a, comparison between AIS/MIA and IA. AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma; VATS, video-assisted thoracoscopic surgery; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma kinase.