Table 2. The correlation between EGFR gene copy number status (FISH-positive or FISH-negative) and clinicopathologic characteristics in ESCC patients (n=57).
| Patients’ characteristics | FISH-negative (%) | FISH-positive (%) | No. (%) | P values* |
|---|---|---|---|---|
| Gender | 0.283 | |||
| Male | 21 (36.8) | 27 (47.4) | 48 (84.2) | |
| Female | 6 (10.5) | 3 (5.3) | 9 (15.8) | |
| Tumor location | 0.392 | |||
| Upper segment | 2 (3.5) | 1 (1.8) | 3 (5.3) | |
| Middle segment | 20 (35.1) | 19 (33.3) | 39 (68.4) | |
| Lower segment | 5 (8.8) | 10 (17.5) | 15 (26.3) | |
| Differentiation | 0.380 | |||
| High (G1) | 6 (10.5) | 7 (12.3) | 13 (22.8) | |
| Moderate (G2) | 18 (31.6) | 14 (24.6) | 32 (56.1) | |
| Low (G3) | 3 (5.3) | 9 (15.8) | 12 (21.1) | |
| p-T stage | 0.481 | |||
| T1 | 6 (10.5) | 4 (7.0) | 10 (17.5) | |
| T2 | 2 (3.5) | 2 (3.5) | 4 (7.0) | |
| T3 | 19 (33.3) | 22 (38.6) | 41 (71.9) | |
| T4 | 0 (0.0) | 2 (3.5) | 2 (3.5) | |
| p-N stage | 0.008 | |||
| N0 | 16 (28.1) | 8 (14.0) | 24 (42.1) | |
| N1 | 9 (15.8) | 8 (14.0) | 17 (29.8) | |
| N2 | 1 (1.8) | 10 (17.5) | 11 (19.3) | |
| N3 | 1 (1.8) | 4 (7.0) | 5 (8.8) | |
| p-TNM stage | 0.007 | |||
| Stage I | 7 (12.3) | 2 (3.5) | 9 (15.8) | |
| Stage II | 12 (21.1) | 7 (12.3) | 19 (33.3) | |
| Stage III | 8 (14.0) | 21 (36.8) | 29 (50.9) | |
| Length of tumor (cm) | 0.292 | |||
| <4 | 16 (28.1) | 13 (22.8) | 29 (50.9) | |
| ≥4 | 11 (19.3) | 17 (29.8) | 28 (49.1) | |
| Age (years) | 0.597 | |||
| <60 | 11 (19.3) | 15 (26.3) | 26 (45.6) | |
| ≥60 | 16 (28.1) | 15 (26.3) | 31 (54.4) |
*, P values were calculated by using chi-square or Fisher exact tests. T, tumor; N, lymph node; M, metastasis; EGJ, esophago-gastric junction; FISH, fluorescent in situ hybridization; ESCC, esophageal squamous cell carcinoma; EGFR, epidermal growth factor receptor; TNM, tumor, node, metastases.