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. 2016 Jul;8(7):1704–1711. doi: 10.21037/jtd.2016.06.31

Table 1. Features of the studies included in the systemic review.

Study design First author Year Country NOX isoforms Specimens Data entry format
Level of NOX expression or activity Morre J 1997 USA NOX activity Human lung tissue Mean/SD/N
Ilonen I 2009 Finland NOX activity Human lung tissue N/P value
Luxen S 2008 USA DUOX1/2 mRNA Human lung tissue N/P value
Zhang CX* 2014 China NOX4 protein Human lung tissue N/P value
Metastatic lung cancer incidence Kelkka T 2013 Italy NOX2 Knockout Mice Rate/N
Zhang B 2013 China NOX4 siRNA Mice Rate/N
Zhang CX* 2014 China NOX4 overExp Mice Rate/N
NOX level and cancer invasion Boudreau HE 2014 USA NOX4 induction Cancer cell line Mean/SD/N
Vaid M 2014 USA NOX inhibitor, DPI A549 cells N/P value
Liu XY 2015 China DPI, NOX1-siRNA Primary NSCLC N/P value
Yan S 2015 China NOX inhibitor, DPI Primary NSCLC Mean/SD/N
A549 cells N/P value
95D cells N/P value

*, Zhang CX did both experiments. NOX, NADPH oxidase; SD, standard deviation; DPI, diphenyleneiodonium, NOX inhibitor.

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