Table 2. Univariate and multivariate analysis of prognostic factors after lung metastasectomy (Cox proportional hazards regression model).
| Factors | Univariate models | Multivariate model | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio | P | 95% CI | Hazard ratio | P | 95% CI | ||||
| Upper | Lower | Upper | Lower | ||||||
| CRCa pTNM stage (I–II as reference) | |||||||||
| III–IV | 1.456 | 0.134 | 0.891 | 2.382 | 1.906 | 0.019 | 1.112 | 3.268 | |
| Charlson Comorbidity Index (age-adjusted) | 1.068 | 0.077 | 0.993 | 1.150 | 1.071 | 0.119 | 0.982 | 1.168 | |
| Number of MTSb (1 as reference) | |||||||||
| 2–4 | 0.991 | 0.971 | 0.607 | 1.619 | 0.886 | 0.645 | 0.531 | 1.480 | |
| ≥5 | 2.365 | 0.021 | 1.138 | 4.913 | 2.748 | 0.0092 | 1.285 | 5.876 | |
| MTS size (>20 mm) | 1.326 | 0.283 | 0.792 | 2.219 | 1.171 | 0.575 | 0.674 | 2.033 | |
| Lymph node involvement (N0 as reference) | |||||||||
| N+ | 3.633 | <0.0001 | 1.957 | 6.745 | 4.866 | <0.0001 | 2.370 | 9.992 | |
| Nx | 1.244 | 0.516 | 0.644 | 2.405 | 1.254 | 0.532 | 0.617 | 2.547 | |
| Resection status (R0 as reference) | 1.446 | 0.325 | 0.694 | 3.013 | 0.990 | 0.982 | 0.435 | 2.257 | |
| DFI (>30 months)c | 1.080 | 0.736 | 0.689 | 1.694 | 1.227 | 0.401 | 0.762 | 1.974 | |
| Adjuvant chemotherapy (yes) | 1.034 | 0.885 | 0.654 | 1.636 | 0.674 | 0.147 | 0.396 | 1.148 | |
a, colorectal cancer; b, metastasis; c, disease free interval. CI, confidence interval.