Figure 4.

Regional variation in age, amyloid-β, and Alzheimer’s disease-related changes in glucose metabolism. Regional FDG SUVR (solid lines) and PiB DVR (dotted lines) values are plotted for frontal cortex (A) and precuneus by hemisphere (B). FDG SUVR values from frontal cortex (Frontal) and precuneus (Pcu) are plotted to demonstrate a significant interaction effect between region and group (C). Similar patterns of FDG and PiB across groups were observed in frontal, parietal and temporal cortices, and caudate. Posterior cingulate cortex, putamen, and hippocampus regions of interest showed a pattern of FDG change across groups that resembles precuneus. L = left; R = right; Y = young.