Table 1.
Characteristics of participants
| Young | PiB− OLD | PiB+ OLDa | Alzheimer’s disease | |
|---|---|---|---|---|
| n | 9 | 64 | 32 | 20 |
| Age, years | 24.9 ± 3.6 (20–30) | 74.1 ± 5.7 (61–88) | 75.5 ± 7.3 (61–96) | 68.5 ± 10.6 (50–90) |
| Education, years | 16.0 ± 2.1 (14–20) | 17.1 ± 1.9 (12–20) | 16.8 ± 1.7 (13–20) | 16.9 ± 2.7 (9–22) |
| Gender, n, F/M b | 5/4 | 40/24 | 19/13 | 12/8 |
| PiB index | 1.02 ± 0.03 (1–1.07) | 1.01 ± 0.05(0.8–1.07) | 1.29 ± 0.22(1.08–1.8) | 1.63 ± 0.15 (1.3–1.9) |
| APOE-ε4, n(%)c | 5 (62.5%) | 13 (22.6%) | 15 (46.9%) | 10 (58.8%) |
| MMSE | 28.6 ± 1.5 (26–30) | 29.0 ± 1.2 (25–30) | 28.7 ± 1.4 (25–30) | 21 ± 6.7(1–29) |
Values are presented as mean ± SD (range). MMSE = Mini-Mental State Examination.
aClassified as PiB+ if PiB index was greater than mean +2 SD of the PiB index of young adults. The resulting cut-off score was 1.08.
bχ2 = 0.5, P > 0.9.
cProportion of individuals with APOE genotypes ε3/4 or ε4/4, χ2 = 14.4, P = 0.0.