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. 2016 Jun 12;139(8):2224–2234. doi: 10.1093/brain/aww124

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© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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graphic file with name aww124fig1g.jpg — See Postuma (doi:10.1093/aww131) for a scientific commentary on this article.

Idiopathic REM sleep behaviour disorder (RBD) is associated with frequent conversion to Parkinson’s disease. Rolinski et al. show that resting-state fMRI differentiates cases of RBD and Parkinson’s disease from controls with high sensitivity (96%) and specificity (74–78%). Basal ganglia network connectivity may reveal future Parkinson’s disease before motor symptom onset.