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. 2016 Aug 19;371(1701):20150445. doi: 10.1098/rstb.2015.0445

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — Differentiation graph for three cell types. Nodes represent cell type, arrows indicate that the cell type pointed to will be present in an adult that originated in a spore of the originating cell type. (a) Original differentiation graph. (b) Differentiation graph with epimutation in which A mutates to A′, and this epimutation is lost in the differentiation to B and C. (c) Differentiation graph in which A is mutated to A′. The epimutation is retained in differentiation to B, which leads to the creation of B′. The epimutation is lost in differentiation of A′ and B′ into C.