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. 2016 Jul 25;6:30085. doi: 10.1038/srep30085

Figure 6. α2A-ERK/AKT axis mediates the pro-catabolic effects of norepinephrine.

Figure 6

(A–C) Western blot of the expression of p-ERK, total ERK, p-JNK, total JNK, p-p38, total p38, p-AKT and total AKT by chondrocytes after NE stimulation (N = 3). The chondrocytes were treated by 10−8 M NE for 15, 30 or 60 min, and treated 30 min by NE of 10−6, 10−7 or 10−8 M. (D,E) Western blot of the expression of p-ERK, total ERK, p-AKT and total AKT by chondrocytes after NE stimulation in accompanied with different adrenorecptors antagonist (N = 3). Chondrocytes were stimulated by 10−7 M NE for 30 min alone, or pre-treated for 1 h with 10−5 μM doxazosin (Dox), yohimbine (Yoh) or propranolol (Pro). **P < 0.01: vs NE-treated chondrocytes.